{"id":"W2130264065","doi":"10.1016/j.ccr.2014.05.005","title":"Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma","year":2014,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":310,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Hospital for Sick Children; Ontario College of Art and Design; University of Toronto; SickKids Foundation; BC Cancer Agency","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Brain Tumour Research; Hospital for Sick Children; Genome British Columbia; Howard Hughes Medical Institute; Government of Ontario; Canadian Institutes of Health Research; Genome Canada","keywords":"Medulloblastoma; SOX2; Smoothened; Sonic hedgehog; Biology; Cancer research; Progenitor cell; Hedgehog signaling pathway; Population; Stem cell; Cell biology; Medicine; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731139,0.0002137456,0.0002320727,0.00003766037,0.00007491065,0.0000188327,0.0001694825,0.0001648326,0.00001926396],"category_scores_gemma":[0.00004910269,0.0002048449,0.00006407234,0.00007928175,0.0001878263,0.000004166297,0.0001876699,0.0001687022,0.00001209794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004879969,"about_ca_system_score_gemma":0.00008096647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001511464,"about_ca_topic_score_gemma":0.0005956542,"domain_scores_codex":[0.9986513,0.000105399,0.0002224597,0.0005060273,0.0001241949,0.0003906637],"domain_scores_gemma":[0.9994678,0.00003489967,0.00006421646,0.0002560437,0.00004050428,0.0001365391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000840357,0.00007887134,0.007529765,0.0001174232,0.00002799525,0.000007107867,0.000538903,0.00004701184,0.9882599,0.0001472093,0.001654955,0.001506897],"study_design_scores_gemma":[0.001244675,0.0003519951,0.004148189,0.00006137895,0.0000232158,0.000003523479,0.0001864048,0.0001683979,0.9768332,0.0001414767,0.01646148,0.0003760196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915055,0.004865091,0.0004216865,0.000221941,0.000316972,0.000169981,0.00001446338,0.00001808988,0.00246625],"genre_scores_gemma":[0.9962653,0.002163352,0.0002484262,0.0005208642,0.0003108218,0.00005157873,0.0000137544,0.00003420182,0.0003917179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01480652,"threshold_uncertainty_score":0.8353334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005594805532518266,"score_gpt":0.2203838253503264,"score_spread":0.2147890198178082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}