{"id":"W2130273718","doi":"10.1210/en.2003-1274","title":"Insulin-Like Growth Factor (IGF)-I/IGF-Binding Protein-3 Complex: Therapeutic Efficacy and Mechanism of Protection against Type 1 Diabetes","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials; Diabetes Canada","funders":"","keywords":"Insulitis; Endocrinology; Internal medicine; Islet; Biology; Growth factor; Protein kinase B; Insulin-like growth factor; Cell growth; Signal transduction; Cancer research; Insulin; Receptor; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008218902,0.0001913105,0.0004324722,0.0001963722,0.00009073016,0.00000945515,0.000054293,0.0001012339,0.000221633],"category_scores_gemma":[0.0005785132,0.0001622391,0.00005154751,0.0002151443,0.000128641,0.00005045413,0.0000279852,0.000222281,0.00005089205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005090304,"about_ca_system_score_gemma":0.00007412568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001047815,"about_ca_topic_score_gemma":0.00000133998,"domain_scores_codex":[0.998753,0.0001490313,0.0002809153,0.000292144,0.0001393922,0.0003854784],"domain_scores_gemma":[0.999286,0.0001207999,0.0001256407,0.000214378,0.0001532272,0.00009998393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001298944,0.0001910189,0.005831264,0.0001686042,0.0001865895,0.000008360745,0.0001417249,4.121197e-7,0.9745423,0.01481423,0.00004684872,0.003938717],"study_design_scores_gemma":[0.005445004,0.002072314,0.01988535,0.0001197624,0.000133296,0.00005200202,0.0001873073,0.0001366673,0.9655331,0.002100776,0.004040595,0.0002938003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947979,0.0004997157,0.0001677237,0.0002701921,0.0003081725,0.000911827,0.000005160082,0.0001114753,0.002927864],"genre_scores_gemma":[0.9983289,0.00008572073,0.0005751941,0.0004026324,0.00004430145,0.00006556742,0.0000130166,0.00002593949,0.0004587671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01405408,"threshold_uncertainty_score":0.6615916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04261954232802747,"score_gpt":0.2635627390576014,"score_spread":0.2209431967295739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}