{"id":"W2130273718","doi":"10.1210/en.2003-1274","title":"Insulin-Like Growth Factor (IGF)-I/IGF-Binding Protein-3 Complex: Therapeutic Efficacy and Mechanism of Protection against Type 1 Diabetes","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials; Diabetes Canada","funders":"","keywords":"Insulitis; Endocrinology; Internal medicine; Islet; Biology; Growth factor; Protein kinase B; Insulin-like growth factor; Cell growth; Signal transduction; Cancer research; Insulin; Receptor; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672842,0.0004968695,0.0002759252,0.0003203062,0.0001236382,0.0003273895,0.00024304,0.0002668124,0.0007466794],"category_scores_gemma":[0.00006631135,0.00008834983,0.0002486622,0.0002176992,0.0002407018,0.0002057985,0.0001393563,0.0007438046,0.0001302266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005298432,"about_ca_system_score_gemma":0.0002762179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008475222,"about_ca_topic_score_gemma":0.0009523488,"domain_scores_codex":[0.9999251,0.00001077814,0.000004847092,0.00001102849,0.00002258244,0.00002559404],"domain_scores_gemma":[0.999962,0.000002869057,0.00001300559,0.000002804401,0.000004181973,0.00001522038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001638236,0.0002120661,0.000336914,0.0002096606,0.00003433318,0.00008471756,0.00001726858,0.0002107602,0.9783527,0.0002768204,0.0001781479,0.01844847],"study_design_scores_gemma":[0.0005924945,0.004605825,0.01437409,0.00004026872,0.000180251,0.0008454781,0.00003089153,0.001243328,0.9671139,0.0002538323,0.01069373,0.000025976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598258,0.03156386,0.004925195,0.0005186522,0.0001477395,0.00009588595,0.0004536579,0.0002123868,0.002256805],"genre_scores_gemma":[0.9892092,0.006799276,0.002555482,0.0001094735,0.00003919252,0.00003781941,0.0002638323,0.00001120364,0.0009744604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008475222,"threshold_uncertainty_score":0.003844261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04261954232802747,"score_gpt":0.2635627390576014,"score_spread":0.2209431967295739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}