{"id":"W2130282569","doi":"10.2147/ijn.s26571","title":"Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery","year":2012,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chitosan; Polynucleotide; Cytotoxicity; Oligonucleotide; Small interfering RNA; Gene knockdown; Transfection; Nanoparticle; RNA; Biophysics; Chemistry; Nuclear chemistry; In vitro; Molecular biology; Materials science; Nanotechnology; Biochemistry; DNA; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283975,0.0001772167,0.0002468974,0.0001449408,0.00005180105,0.00002196506,0.0003923989,0.0001008332,0.00003947849],"category_scores_gemma":[0.00008456167,0.0001427639,0.0002354299,0.00005172645,0.00006294571,0.00002790801,0.00009413833,0.00008686745,0.000016853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000840294,"about_ca_system_score_gemma":0.00008399637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000053007,"about_ca_topic_score_gemma":0.000002954123,"domain_scores_codex":[0.9985505,0.00004355367,0.0005665504,0.0001627645,0.0003924576,0.0002842028],"domain_scores_gemma":[0.998798,0.000025286,0.0004026916,0.0001744852,0.0004037469,0.00019584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005516557,0.000120055,0.002913217,0.00002657924,0.0003872659,0.00004511818,0.00007857716,0.0001011111,0.9922716,0.0000721723,0.002247857,0.001184791],"study_design_scores_gemma":[0.001802015,0.0005707032,0.00248371,0.0002353547,0.00007797239,0.0006180141,0.0001062161,0.0001757441,0.9872723,0.000005610659,0.006485303,0.0001671067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887006,0.00206871,0.005573083,0.0005619822,0.002703476,0.0001426668,0.00002714498,0.000006383631,0.000215976],"genre_scores_gemma":[0.9957787,0.0002023692,0.0004247988,0.0006414879,0.002577656,0.000009104268,0.00006774386,0.00002450796,0.0002736675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007078086,"threshold_uncertainty_score":0.5821741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006123584961640041,"score_gpt":0.2428606249307263,"score_spread":0.2367370399690862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}