{"id":"W2130282569","doi":"10.2147/ijn.s26571","title":"Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery","year":2012,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chitosan; Polynucleotide; Cytotoxicity; Oligonucleotide; Small interfering RNA; Gene knockdown; Transfection; Nanoparticle; RNA; Biophysics; Chemistry; Nuclear chemistry; In vitro; Molecular biology; Materials science; Nanotechnology; Biochemistry; DNA; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159267,0.0004519241,0.0002088339,0.0002451216,0.0001932008,0.0002590241,0.0002636646,0.0003648876,0.0007736462],"category_scores_gemma":[0.0001730014,0.000135442,0.0001979515,0.0001628593,0.0001703784,0.0002482523,0.0001887874,0.0004551907,0.0003358629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005409417,"about_ca_system_score_gemma":0.0004172507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485175,"about_ca_topic_score_gemma":0.002231696,"domain_scores_codex":[0.999872,0.00001517917,0.00001281681,0.00003480992,0.00004663603,0.00001852334],"domain_scores_gemma":[0.9999294,0.00001285051,0.00001899094,0.000005436052,0.0000234228,0.000009977703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001568305,0.000009248147,0.00002464254,0.00003205725,0.000001858399,0.00001673381,0.000004569201,0.0000706089,0.9987992,0.00004591612,0.0000345968,0.0009448083],"study_design_scores_gemma":[0.000006118057,0.0001213992,0.0001883838,0.000002521562,0.000009378118,0.00006499513,0.00000319844,0.0007679426,0.9977279,0.00001490178,0.001088461,0.000004806709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9418907,0.003258452,0.0491956,0.0003765098,0.0000893596,0.0002301657,0.0002979611,0.0004574969,0.004203781],"genre_scores_gemma":[0.9718947,0.001127839,0.02298784,0.000122861,0.00001699281,0.000161639,0.0002482312,0.00004443305,0.003395411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001485175,"threshold_uncertainty_score":0.003924847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006123584961640041,"score_gpt":0.2428606249307263,"score_spread":0.2367370399690862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}