{"id":"W2130290558","doi":"10.1128/aac.00380-10","title":"Depolarization, Bacterial Membrane Composition, and the Antimicrobial Action of Ceragenins","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antimicrobial; Depolarization; Chemistry; Membrane; Microbiology; Biology; Biophysics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011666,0.0002443661,0.000402748,0.00007473333,0.0005015188,0.00007975377,0.0001602991,0.0002526523,0.0005304755],"category_scores_gemma":[0.000009111638,0.0001786313,0.0001077584,0.00008783077,0.001446513,0.000193777,0.00007479636,0.0003160915,0.00001423865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006527555,"about_ca_system_score_gemma":0.00003817134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997164,"about_ca_topic_score_gemma":0.00006949058,"domain_scores_codex":[0.9989183,0.0001121477,0.0003616277,0.0003039882,0.00003578215,0.0002681891],"domain_scores_gemma":[0.999367,0.00008283422,0.0002337939,0.0002087138,0.0000813166,0.00002634352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007551619,0.0001281861,0.001935321,0.00004432685,0.0001692839,7.640919e-7,0.0005963438,0.000001592331,0.9849824,0.001354694,0.007769135,0.00226275],"study_design_scores_gemma":[0.006358079,0.00004832734,0.008900419,0.00003601607,0.00008472609,0.0001761339,0.00005876436,0.00001301555,0.9645257,0.00007297246,0.01945936,0.0002665092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950322,0.00002860101,0.0002523813,0.003050787,0.0009487123,0.00033542,0.00008719806,0.00004055445,0.0002241458],"genre_scores_gemma":[0.9956115,0.0009760736,0.0002891902,0.00237296,0.0001543408,0.000003465907,0.0001587797,0.00002918286,0.000404522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02045676,"threshold_uncertainty_score":0.7284372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008346161941142316,"score_gpt":0.2246389260914944,"score_spread":0.216292764150352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}