{"id":"W2130290719","doi":"10.1161/circulationaha.115.016382","title":"Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Downregulation and upregulation; Medicine; Angiogenesis; CD31; Heart failure; Internal medicine; Vascular endothelial growth factor; MAPK/ERK pathway; Pulmonary hypertension; Vascular endothelial growth factor A; Neovascularization; Endocrinology; Cardiology; Cancer research; Kinase; Biology; Cell biology; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002958527,0.00008618259,0.00019937,0.0003297119,0.00004952312,0.00001135769,0.00005269253,0.00006477429,0.00001744822],"category_scores_gemma":[0.0002257911,0.0000586341,0.0000492252,0.0007261717,0.00002922766,0.00009605215,0.00002937067,0.00007151531,0.00005086028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001257837,"about_ca_system_score_gemma":0.00008398525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001056354,"about_ca_topic_score_gemma":0.00001074727,"domain_scores_codex":[0.9990171,0.00007216507,0.0002563061,0.0001826977,0.0002916285,0.0001800841],"domain_scores_gemma":[0.9992799,0.00005642285,0.00005765537,0.0002286282,0.0002589522,0.000118446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001384921,0.0006862947,0.3035752,0.00003391794,0.00005531152,0.0005099879,0.0001239361,0.00138211,0.680281,0.0001380959,0.0007025356,0.01112664],"study_design_scores_gemma":[0.00202745,0.00006425082,0.975449,0.00008777335,0.00004165883,0.0001183513,0.00007193461,0.01401641,0.00640997,0.0004942388,0.001162338,0.00005661378],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956066,0.0004861472,0.0002523517,0.002645587,0.0001280258,0.0006412426,0.000006123701,0.00001725975,0.0002166545],"genre_scores_gemma":[0.9994373,0.000007171473,0.0001251763,0.0001659886,0.00008633068,0.00001809567,0.0001144341,0.000009251639,0.00003620657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6738711,"threshold_uncertainty_score":0.2391029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384558780375479,"score_gpt":0.280262245468108,"score_spread":0.2418063674305601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}