{"id":"W2130311846","doi":"10.1161/atvbaha.110.205500","title":"Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro","year":2010,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Environmental Health Sciences","keywords":"Liver X receptor; Retinoid X receptor; ABCA1; Nuclear receptor; Arsenic; Receptor; Retinoid X receptor alpha; Transcription factor; Efflux; Biology; ABCG1; Chromatin immunoprecipitation; Chemistry; Biochemistry; Promoter; Gene expression; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004591102,0.0001140786,0.0002427856,0.00007801112,0.00004035642,0.000006451053,0.00008784528,0.0001333329,0.0001264496],"category_scores_gemma":[0.00008317217,0.00008923801,0.00007203717,0.0002757411,0.0002300351,0.00007647099,0.00005124844,0.0001234664,0.00002124038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003481695,"about_ca_system_score_gemma":0.000006783844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002943121,"about_ca_topic_score_gemma":0.001351417,"domain_scores_codex":[0.9989646,0.0002157522,0.0003185305,0.0002459596,0.00008512185,0.0001700421],"domain_scores_gemma":[0.9995838,0.0001010343,0.000101985,0.000161973,0.00001584207,0.00003531777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000007209115,0.0001026391,0.04482475,0.00001595219,0.00001326273,1.247569e-8,0.001278405,0.000001688397,0.9503755,0.00006789772,0.00002103663,0.003291654],"study_design_scores_gemma":[0.0006181793,0.0000886265,0.6918622,0.00003269004,0.00001101511,5.060485e-8,0.00007449621,0.00008899681,0.3067932,0.00002482692,0.0003400485,0.00006567901],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986258,0.00004138418,0.0001885354,0.0003940619,0.0001257884,0.0005851788,0.00001438618,0.000008531371,0.00001633637],"genre_scores_gemma":[0.9988629,0.0006100793,0.0002440776,0.0001467556,0.000009473035,0.00008157462,0.00003560011,0.000007895161,0.000001600512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6470374,"threshold_uncertainty_score":0.3639021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008225834026778357,"score_gpt":0.2172143444925098,"score_spread":0.2089885104657314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}