{"id":"W2130311846","doi":"10.1161/atvbaha.110.205500","title":"Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro","year":2010,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Environmental Health Sciences","keywords":"Liver X receptor; Retinoid X receptor; ABCA1; Nuclear receptor; Arsenic; Receptor; Retinoid X receptor alpha; Transcription factor; Efflux; Biology; ABCG1; Chromatin immunoprecipitation; Chemistry; Biochemistry; Promoter; Gene expression; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006063998,0.0005259103,0.000605623,0.0001822463,0.0002394235,0.0003386203,0.0003098982,0.0002769603,0.00194821],"category_scores_gemma":[0.0002098249,0.0002387144,0.0005447792,0.000192593,0.0003102518,0.0001759743,0.000247309,0.0005940599,0.0008934094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575876,"about_ca_system_score_gemma":0.0003419326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008442827,"about_ca_topic_score_gemma":0.001574087,"domain_scores_codex":[0.9994579,0.0001655298,0.00005743641,0.00007631457,0.0001504471,0.00009236987],"domain_scores_gemma":[0.9997929,0.00008415952,0.00002781171,0.00003640118,0.00003762138,0.00002112048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003291249,0.0001138047,0.0001361441,0.00009468473,0.00001373349,0.00003404287,0.00002299639,0.00007418945,0.9980845,0.00004744263,0.00006660892,0.0009828035],"study_design_scores_gemma":[0.00004451493,0.0007502165,0.001258273,0.000008172598,0.00003079768,0.00008719882,0.00002146726,0.0006869313,0.9945768,0.0000293424,0.002502089,0.000004241712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773453,0.008196493,0.008718679,0.0004178073,0.0001898379,0.00009091875,0.000567042,0.0001615219,0.004312325],"genre_scores_gemma":[0.978116,0.005391011,0.006452764,0.0001928507,0.0001302073,0.0001682176,0.001408325,0.00005808972,0.008082449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00194821,"threshold_uncertainty_score":0.00651741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008225834026778357,"score_gpt":0.2172143444925098,"score_spread":0.2089885104657314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}