{"id":"W2130325118","doi":"10.3748/wjg.15.3134","title":"Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease","year":2009,"lang":"en","type":"article","venue":"World Journal of Gastroenterology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tauroursodeoxycholic acid; FGF19; Glycocholic acid; Ursodeoxycholic acid; Chenodeoxycholic acid; Bile acid; Gastroenterology; Internal medicine; Ulcerative colitis; Cholic acid; Deoxycholic acid; Inflammatory bowel disease; Lithocholic acid; Primary sclerosing cholangitis; Taurocholic acid; Enterohepatic circulation; Medicine; Bile acid malabsorption; Chemistry; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003567369,0.0001372121,0.000272712,0.0004629241,0.00003637154,0.00001350022,0.00006403158,0.00002896733,0.0000345878],"category_scores_gemma":[0.0000347353,0.0001119936,0.0000751834,0.0001007667,0.00005450384,0.0001421171,0.00000824461,0.0003478253,0.000002362293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000751495,"about_ca_system_score_gemma":0.00006620353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.834242e-7,"about_ca_topic_score_gemma":0.0001007653,"domain_scores_codex":[0.9987539,0.00008024586,0.000555385,0.000159323,0.000179761,0.0002713675],"domain_scores_gemma":[0.9992344,0.00001261468,0.0002837315,0.0001170418,0.000107479,0.0002447693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01034416,0.0001501035,0.9186271,0.00008399653,0.0000304542,0.0004222228,0.0001193727,0.00005037056,0.06792695,0.00003987058,0.00003173731,0.002173614],"study_design_scores_gemma":[0.002654287,0.002063315,0.9903934,0.0004024354,0.0001131743,0.0002206415,0.0000570042,0.0002159842,0.002901081,0.0008062226,0.0001133631,0.0000590844],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928154,0.0002787758,0.004938381,0.001489607,0.0002417131,0.0001842471,0.000002403094,0.00001090315,0.00003858956],"genre_scores_gemma":[0.9968463,0.00007733613,0.001998864,0.0007997053,0.00009796137,0.000004106957,0.000005308147,0.00001121288,0.0001592449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07176626,"threshold_uncertainty_score":0.4566965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007871376359141247,"score_gpt":0.2377181965601953,"score_spread":0.229846820201054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}