{"id":"W2130343520","doi":"10.1084/jem.194.12.1777","title":"The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis","year":2001,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Wiskott–Aldrich syndrome protein; Endocytic cycle; Cell biology; Endocytosis; Biology; T-cell receptor; Internalization; GTPase; CDC42; Signal transducing adaptor protein; Actin; Actin cytoskeleton; T cell; Cytoskeleton; Signal transduction; Receptor; Immunology; Cell; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162416,0.000374106,0.0001525085,0.0003428057,0.000312626,0.0004807661,0.0001188045,0.0002994972,0.00100845],"category_scores_gemma":[0.0001782207,0.0001974863,0.0001842169,0.0001887134,0.0002857644,0.000243399,0.0003790052,0.0004392166,0.0004093684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004657005,"about_ca_system_score_gemma":0.0002374099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004034147,"about_ca_topic_score_gemma":0.0007524331,"domain_scores_codex":[0.9998325,0.0000403765,0.00001486725,0.00002284429,0.00004383116,0.00004549599],"domain_scores_gemma":[0.9999115,0.00001183058,0.00002828854,0.00001060764,0.000008595079,0.00002912837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531694,0.00001598217,0.0004267102,0.00002916106,0.000007838315,0.0003143729,0.000009243106,0.00009622686,0.9976969,0.0003272788,0.00008100456,0.0008419589],"study_design_scores_gemma":[0.00003308054,0.0002064281,0.01330932,0.00001311761,0.00003280942,0.002373073,0.00004798981,0.00239959,0.9761861,0.0002717217,0.005119763,0.000007033976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995373,0.001557456,0.00140544,0.0001260909,0.00001914865,0.00001108538,0.0001252952,0.00005654683,0.00132613],"genre_scores_gemma":[0.994876,0.001678653,0.001281664,0.00004145393,0.00001548954,0.00001359921,0.0003591739,0.000009097044,0.001724929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00100845,"threshold_uncertainty_score":0.003378928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169211302803201,"score_gpt":0.3084025194796212,"score_spread":0.2867104064515891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}