{"id":"W2130364248","doi":"10.1002/jhet.5570390631","title":"Synthesis of 4‐alkyl‐1,2‐diphenyl‐3,5‐dioxopyrazolidines possessing aryl methylsulfonyl and sulfonamide pharmacophores for evaluation as selective cyclooxygenase‐2 (COX‐2) inhibitors","year":2002,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Substituent; Sulfonamide; Aryl; Aniline; Acetic anhydride; Stereochemistry; Ring (chemistry); Medicinal chemistry; Aromatization; Chloroacetyl chloride; Alkyl; Chloride; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578132,0.0004017379,0.0003512651,0.0002290789,0.0001065109,0.0001477879,0.0003394354,0.000228317,0.001617825],"category_scores_gemma":[0.0001138548,0.0001938757,0.0001782147,0.0001628868,0.0001288448,0.0001361163,0.0001587432,0.0002926624,0.0006760529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002330025,"about_ca_system_score_gemma":0.0004330105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004691927,"about_ca_topic_score_gemma":0.001385149,"domain_scores_codex":[0.9999152,0.00001288629,0.00000873157,0.00001414585,0.00001954581,0.00002949813],"domain_scores_gemma":[0.9999315,0.000006254591,0.00001810934,0.000006530782,0.00001446018,0.00002321678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002234556,0.00009413328,0.0001274832,0.0002466152,0.00001273253,0.0001536523,0.00003028096,0.0004082577,0.991636,0.0003912926,0.0002139337,0.006462175],"study_design_scores_gemma":[0.0004416145,0.005658989,0.004426184,0.00003724097,0.0000850387,0.0005139482,0.00003718202,0.001877252,0.9694644,0.0001106972,0.0173074,0.00003997591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652552,0.009552348,0.01314066,0.0001877271,0.0001948995,0.0005936805,0.001962056,0.000422173,0.008691261],"genre_scores_gemma":[0.9774218,0.003670839,0.0124584,0.0001078749,0.00002838763,0.0002737174,0.000969162,0.0000184102,0.005051412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617825,"threshold_uncertainty_score":0.005412161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645789600566231,"score_gpt":0.2996533193043387,"score_spread":0.2831954232986764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}