{"id":"W2130364248","doi":"10.1002/jhet.5570390631","title":"Synthesis of 4‐alkyl‐1,2‐diphenyl‐3,5‐dioxopyrazolidines possessing aryl methylsulfonyl and sulfonamide pharmacophores for evaluation as selective cyclooxygenase‐2 (COX‐2) inhibitors","year":2002,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Substituent; Sulfonamide; Aryl; Aniline; Acetic anhydride; Stereochemistry; Ring (chemistry); Medicinal chemistry; Aromatization; Chloroacetyl chloride; Alkyl; Chloride; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007987024,0.0002960478,0.0007748318,0.0001591965,0.0001082118,0.0000288174,0.0001223696,0.0001978714,0.0001403849],"category_scores_gemma":[0.001678189,0.000249018,0.0003408107,0.000178594,0.0001297699,0.0002200575,0.00003330637,0.0003397526,0.000002261389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013096,"about_ca_system_score_gemma":0.00009570044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009467984,"about_ca_topic_score_gemma":6.869822e-7,"domain_scores_codex":[0.9977413,0.0000587779,0.0009068457,0.0002688327,0.0007030588,0.0003212063],"domain_scores_gemma":[0.9973565,0.0006320378,0.0009266519,0.000195286,0.0006065371,0.0002829872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006945015,0.000195072,0.002707095,0.0009310493,0.0003476689,0.00005384286,0.0003762069,0.00003061691,0.9788057,7.964418e-7,0.001431294,0.0144262],"study_design_scores_gemma":[0.003775483,0.0002314498,0.002166806,0.0007236312,0.0008736318,0.0008662481,0.0002041259,0.001804147,0.9886541,0.0001222544,0.0003651518,0.0002129729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936253,0.004923698,0.00002648928,0.0002500259,0.0003028801,0.0003946816,0.00001299438,0.0000164732,0.0004475032],"genre_scores_gemma":[0.9975697,0.0006334226,0.000408443,0.00007287418,0.001174147,0.00003610924,0.000004706746,0.0000445188,0.00005608178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01421322,"threshold_uncertainty_score":0.9999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645789600566231,"score_gpt":0.2996533193043387,"score_spread":0.2831954232986764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}