{"id":"W2130381085","doi":"10.1124/mol.104.005884","title":"Residue 33 of Human Equilibrative Nucleoside Transporter 2 Is a Functionally Important Component of Both the Dipyridamole and Nucleoside Binding Sites","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institutes of Health Research","funders":"","keywords":"Nucleoside; Chemistry; Dipyridamole; Adenosine; Nucleoside transporter; Stereochemistry; Uridine; Purine; Residue (chemistry); Footprinting; Biochemistry; Transporter; Enzyme; DNA; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058529,0.0001920325,0.0002575583,0.00006811222,0.00009540375,0.000008029503,0.0001986361,0.000115603,0.0002749355],"category_scores_gemma":[0.000007610236,0.0001572146,0.0001321698,0.00009465816,0.0002528964,0.00000849312,0.0001019893,0.0001288553,0.00000166311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008844883,"about_ca_system_score_gemma":0.00005168497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003573566,"about_ca_topic_score_gemma":0.000011778,"domain_scores_codex":[0.998715,0.0001071851,0.0004641048,0.0003208937,0.0001556221,0.0002371218],"domain_scores_gemma":[0.9993789,0.00003018595,0.0002484831,0.0002001087,0.00007195405,0.0000704124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977728,0.0001123176,0.004580489,0.00002990532,0.0002690376,0.00001904754,0.0002868875,0.0001795974,0.9856257,0.0002984125,0.008342794,0.00005808159],"study_design_scores_gemma":[0.0009877788,0.0003705594,0.004559559,0.00001423736,0.000156801,0.00002779208,0.00007782957,0.0002299564,0.9889594,0.00009317409,0.004354488,0.0001683854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943944,0.003409785,0.0005665484,0.0009161922,0.00004905483,0.0002319958,0.00006385077,0.000008655746,0.0003595301],"genre_scores_gemma":[0.9976701,0.0001278202,0.0004241579,0.001381109,0.0001521763,0.00001803749,0.00008352299,0.00002913602,0.0001140043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003988307,"threshold_uncertainty_score":0.6411026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126660603830881,"score_gpt":0.2742250290355945,"score_spread":0.2629584229972857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}