{"id":"W2130422028","doi":"10.1074/mcp.m111.014845","title":"Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins Derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes","year":2012,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Microvesicles; Prostate cancer; Microvesicle; Biomarker; Cancer research; Exosome; Proteomics; Tumor microenvironment; Prostate; Biology; Medicine; Cancer; Cell biology; microRNA; Internal medicine; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002432986,0.0004661357,0.000453105,0.00009726732,0.0000720469,0.00003158212,0.0004231913,0.0002782967,0.00003330638],"category_scores_gemma":[0.0001067096,0.0004353686,0.0002142577,0.0002313406,0.0003163178,0.00003189005,0.0002433939,0.0001449907,0.00001232754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003184793,"about_ca_system_score_gemma":0.0002285219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006913586,"about_ca_topic_score_gemma":0.000003832346,"domain_scores_codex":[0.997611,0.0002388111,0.0006503523,0.0006103814,0.0003590886,0.0005303671],"domain_scores_gemma":[0.9978803,0.00001596749,0.000688297,0.0009294529,0.0002544007,0.0002315279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008708435,0.0006397404,0.01113946,0.000255726,0.0001993078,0.00002370595,0.0003522731,0.0000181256,0.986053,0.00003142439,0.000004214336,0.0004121921],"study_design_scores_gemma":[0.001395194,0.0003460503,0.00994882,0.00007277261,0.0001702007,0.000008332874,0.00009313304,0.0001441372,0.9870334,0.000093257,0.0001900767,0.0005046597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585435,0.001935275,0.03733569,0.00003467298,0.00007446207,0.001726591,0.000211743,0.00002923208,0.0001087958],"genre_scores_gemma":[0.9826651,0.00005877577,0.01511583,0.0000680041,0.0001145343,0.0001745368,0.001535543,0.0001346747,0.0001330003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02412157,"threshold_uncertainty_score":0.9998098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008866447404273855,"score_gpt":0.2079987522108909,"score_spread":0.199132304806617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}