{"id":"W2130426185","doi":"10.1111/mmi.12971","title":"Nucleotide Second Messenger‐Mediated Regulation of a Muralytic Enzyme in <i>Streptomyces</i>","year":2015,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Streptomyces coelicolor; Peptidoglycan; Enzyme; Lytic cycle; Streptomyces; Transcription (linguistics); Transcription factor; Cell biology; Transcriptional regulation; Biochemistry; Stringent response; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281925,0.0001988405,0.0002986222,0.0001390375,0.00001381606,0.000007283011,0.0002629375,0.0005221757,0.00005887221],"category_scores_gemma":[0.0001112557,0.0001980209,0.00008420729,0.0002087451,0.0002085197,0.000002898189,0.000184332,0.0001302167,0.00002211777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002369788,"about_ca_system_score_gemma":0.0001058559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002621368,"about_ca_topic_score_gemma":0.0001136397,"domain_scores_codex":[0.9986585,0.0001372903,0.0004018199,0.000429208,0.00004597497,0.0003272237],"domain_scores_gemma":[0.9991971,0.0000104379,0.0001657054,0.0004306561,0.0001202151,0.00007585678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021846,0.00006526888,0.0007896688,0.00001391196,0.00003778289,0.00001086422,0.00002656536,0.00004426044,0.9975603,0.00009246682,0.001083737,0.0001729623],"study_design_scores_gemma":[0.001081298,0.0003596676,0.00115012,0.0000103797,0.00001164011,0.00005915859,0.00003029756,0.00002138561,0.9513246,0.0001280107,0.04562038,0.0002029947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977136,0.0008823915,0.0001516831,0.0002727864,0.0001986428,0.0002134159,0.00005671825,0.00001606507,0.0004946901],"genre_scores_gemma":[0.9981627,0.00003331117,0.0007067293,0.0003114337,0.00004502907,0.00001105959,0.0005392245,0.00002654269,0.0001639121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04623566,"threshold_uncertainty_score":0.8075058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006671160987424959,"score_gpt":0.2075115876556848,"score_spread":0.2008404266682599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}