{"id":"W2130426185","doi":"10.1111/mmi.12971","title":"Nucleotide Second Messenger‐Mediated Regulation of a Muralytic Enzyme in <i>Streptomyces</i>","year":2015,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Streptomyces coelicolor; Peptidoglycan; Enzyme; Lytic cycle; Streptomyces; Transcription (linguistics); Transcription factor; Cell biology; Transcriptional regulation; Biochemistry; Stringent response; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007306549,0.0002233325,0.0001446891,0.0001196717,0.0001422699,0.0002964293,0.0001047195,0.0001596843,0.0003730163],"category_scores_gemma":[0.0001017549,0.00006286713,0.0001422424,0.00007927544,0.0002372864,0.00009098823,0.0001382289,0.0002089761,0.0001714106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003982632,"about_ca_system_score_gemma":0.0001900761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237034,"about_ca_topic_score_gemma":0.001114156,"domain_scores_codex":[0.9999086,0.00001524715,0.000007932569,0.00002480081,0.0000223988,0.00002102069],"domain_scores_gemma":[0.9999301,0.00001533814,0.00002303177,0.000008005327,0.00000706378,0.00001650516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004480674,0.000008086551,0.0001586613,0.00001326309,9.27649e-7,0.00004502924,0.00000894713,0.00007920699,0.9987755,0.0001171115,0.00001707586,0.0007313426],"study_design_scores_gemma":[0.000004566348,0.00008791198,0.00439556,0.0000020836,0.000003516926,0.00007554962,0.00002200018,0.001288062,0.9933541,0.00006842369,0.0006927996,0.000005291845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953961,0.001006915,0.00197125,0.00005550403,0.00002815255,0.00001159032,0.0001348346,0.00009483109,0.001300889],"genre_scores_gemma":[0.9980247,0.000197518,0.001116012,0.00001637686,0.000004459619,0.000007193037,0.0000866168,0.000007613535,0.0005396324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237034,"threshold_uncertainty_score":0.002889633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006671160987424959,"score_gpt":0.2075115876556848,"score_spread":0.2008404266682599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}