{"id":"W2130438822","doi":"10.1093/toxsci/kfm012","title":"Induction of Cytochrome P450 1A1 by Ketoconazole and Itraconazole but not Fluconazole in Murine and Human Hepatoma Cell Lines","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; Aryl hydrocarbon receptor; Cytochrome P450; Azole; Itraconazole; Fluconazole; Chemistry; Pharmacology; CYP2B6; Xenobiotic; Enzyme; Biochemistry; Biology; CYP1A2; Gene; Transcription factor; Microbiology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000267404,0.000357506,0.0003738206,0.0003920307,0.0002262408,0.0003516844,0.0001447141,0.0002454539,0.001636961],"category_scores_gemma":[0.0001827166,0.0002219734,0.0004714253,0.0004702534,0.0002310158,0.0001614954,0.0001738232,0.0005653371,0.0005746928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273392,"about_ca_system_score_gemma":0.0002303942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001837402,"about_ca_topic_score_gemma":0.002858264,"domain_scores_codex":[0.9995354,0.0001302313,0.00005631439,0.00007978685,0.0001161925,0.00008200622],"domain_scores_gemma":[0.9998254,0.00004844928,0.00003153389,0.00004163573,0.00003272323,0.00002019929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002010893,0.0000715381,0.0003513242,0.0000558237,0.00001112208,0.00007053521,0.00003144522,0.00008018797,0.9978186,0.00005461746,0.00008841707,0.001165269],"study_design_scores_gemma":[0.00003429809,0.0007665554,0.007885925,0.000005216224,0.00002404631,0.0002151044,0.0000322033,0.0005132181,0.9880702,0.00001984525,0.002426076,0.000007421657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814028,0.005966813,0.006495812,0.000223302,0.0001107408,0.0001406567,0.002188663,0.0002057219,0.003265434],"genre_scores_gemma":[0.9854358,0.002569348,0.004308806,0.00009288377,0.00003473823,0.0001538023,0.003501164,0.00002631147,0.003877078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837402,"threshold_uncertainty_score":0.005476177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889922342754469,"score_gpt":0.2743919166179233,"score_spread":0.2554926931903787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}