{"id":"W2130438822","doi":"10.1093/toxsci/kfm012","title":"Induction of Cytochrome P450 1A1 by Ketoconazole and Itraconazole but not Fluconazole in Murine and Human Hepatoma Cell Lines","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; Aryl hydrocarbon receptor; Cytochrome P450; Azole; Itraconazole; Fluconazole; Chemistry; Pharmacology; CYP2B6; Xenobiotic; Enzyme; Biochemistry; Biology; CYP1A2; Gene; Transcription factor; Microbiology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00136946,0.0001864365,0.0002680468,0.00007954437,0.00021402,0.00003981773,0.0002982325,0.0001628638,0.001164713],"category_scores_gemma":[0.0001125003,0.0001405558,0.00002436494,0.0005194771,0.001668896,0.0003625683,0.0002869475,0.0001875265,0.00002262727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009891322,"about_ca_system_score_gemma":0.0000182183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325281,"about_ca_topic_score_gemma":0.0003900983,"domain_scores_codex":[0.9980668,0.00006075737,0.0004413571,0.0004971756,0.0004094269,0.0005244794],"domain_scores_gemma":[0.9993227,0.0001637088,0.0001611132,0.0001251126,0.000002969126,0.0002243626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001875058,0.0001762429,0.05111524,0.000003909789,0.000001451422,0.000009680204,0.00009805375,0.000005874446,0.9382232,0.0000645158,0.00004947208,0.0102336],"study_design_scores_gemma":[0.0003740963,0.0004007335,0.6602215,0.000005559131,0.000003375,0.00002189207,0.0001610236,0.00008410691,0.338034,0.0003662049,0.000187145,0.0001404214],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960132,0.0001001277,0.0000284677,0.0003089443,0.00003926167,0.0002891999,0.00003071398,0.00003657833,0.003153478],"genre_scores_gemma":[0.9989334,0.0000288515,0.0005291378,0.0002560263,0.00003210021,0.000004944638,6.652231e-7,0.000006205091,0.0002087142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6091062,"threshold_uncertainty_score":0.9997483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889922342754469,"score_gpt":0.2743919166179233,"score_spread":0.2554926931903787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}