{"id":"W2130440585","doi":"10.1016/j.jmb.2010.09.051","title":"The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Malaria Research and Control","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; McMaster University; University of Toronto","funders":"Canadian Institutes of Health Research; Office of Science; National Institutes of Health; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Ontario Ministry of Research and Innovation; Stiftelsen för Strategisk Forskning; Cancer Research UK; National Center for Research Resources; Ontario Genomics Institute; Wellcome Trust; Industrial Macromolecular Crystallography Association Collaborative Access Team; Stiftelsen för Strategisk Forskning; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; University of Chicago; U.S. Department of Energy","keywords":"Apicoplast; Proteases; Plasmodium falciparum; Biology; Protease; Biochemistry; Proteostasis; Organelle; Cell biology; Malaria; Apicomplexa; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660301,0.0002331061,0.0002775098,0.0002741793,0.0002409246,0.0005413081,0.0001670202,0.000367674,0.0006426445],"category_scores_gemma":[0.0006624546,0.0001686367,0.0001518115,0.0002534993,0.0002179119,0.000428842,0.0002805347,0.0005049637,0.0002418124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293542,"about_ca_system_score_gemma":0.0003616209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156245,"about_ca_topic_score_gemma":0.00112283,"domain_scores_codex":[0.9998662,0.00002644418,0.000007296639,0.00001441014,0.00004212563,0.00004349327],"domain_scores_gemma":[0.9998061,0.00002404592,0.00005307104,0.00001280668,0.00004534959,0.00005868667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002116665,0.00009353069,0.008522807,0.000855332,0.00007545536,0.001838552,0.0003045001,0.001320484,0.9049397,0.004015865,0.007307556,0.06860967],"study_design_scores_gemma":[0.0003255887,0.001389315,0.2097726,0.0001693635,0.0001441124,0.01299377,0.001062584,0.01101323,0.642992,0.007407726,0.112641,0.00008867307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930636,0.05792216,0.003612041,0.002939159,0.0002014904,0.00004691014,0.000574187,0.0001024999,0.003965531],"genre_scores_gemma":[0.9812107,0.01301312,0.001626546,0.0003258183,0.0001500848,0.00001556428,0.0006952743,0.00001530908,0.002947562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156245,"threshold_uncertainty_score":0.002389669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040518397506344,"score_gpt":0.3063525366271883,"score_spread":0.2959473526521248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}