{"id":"W2130491242","doi":"10.1182/blood-2003-07-2365","title":"Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular Profiling Project","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"University of Arizona","keywords":"Immunosurveillance; International Prognostic Index; Human leukocyte antigen; Biology; MHC class I; Diffuse large B-cell lymphoma; CD8; Lymphoma; Immunology; Major histocompatibility complex; Gene expression profiling; CIITA; Cancer research; Internal medicine; Oncology; Antigen; MHC class II; Immune system; Medicine; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220335,0.0003229141,0.0006395471,0.0001018017,0.00009342135,0.00002346455,0.00009446446,0.00009944758,0.000001856459],"category_scores_gemma":[0.0001822799,0.0002086464,0.0000703421,0.0002486051,0.00008024569,0.0000509914,0.0001976539,0.00005418729,3.377882e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269295,"about_ca_system_score_gemma":0.000287484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002820011,"about_ca_topic_score_gemma":0.0001405766,"domain_scores_codex":[0.9980237,0.0001943784,0.000550231,0.0005479024,0.0003854497,0.0002983687],"domain_scores_gemma":[0.998958,0.0001471175,0.0002562469,0.0004180351,0.00009731155,0.0001233248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009461803,0.0171282,0.8586366,0.0001317032,0.0002681403,0.0002300096,0.007216523,8.701287e-7,0.1151177,0.00001022669,0.000001749381,0.0003121624],"study_design_scores_gemma":[0.07402647,0.001808385,0.4315188,0.0007327155,0.0002191133,0.00001830849,0.001509446,0.0000152379,0.4899493,0.00002142259,0.000008227804,0.0001726197],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929566,0.002279515,0.000003604489,0.00005137594,0.00002820058,0.004443515,0.0001954329,0.00002302576,0.00001877674],"genre_scores_gemma":[0.9990464,0.00003369741,0.0004087194,0.00006228007,0.000008050023,0.0003590175,0.00002857716,0.00004407363,0.000009177113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4271178,"threshold_uncertainty_score":0.8508354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008935299649229515,"score_gpt":0.2301296431065388,"score_spread":0.2211943434573093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}