{"id":"W2130491242","doi":"10.1182/blood-2003-07-2365","title":"Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular Profiling Project","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"University of Arizona","keywords":"Immunosurveillance; International Prognostic Index; Human leukocyte antigen; Biology; MHC class I; Diffuse large B-cell lymphoma; CD8; Lymphoma; Immunology; Major histocompatibility complex; Gene expression profiling; CIITA; Cancer research; Internal medicine; Oncology; Antigen; MHC class II; Immune system; Medicine; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004060761,0.0001697281,0.000244179,0.0003682541,0.0002902474,0.0003629811,0.0001385685,0.0002453059,0.0005586881],"category_scores_gemma":[0.000932676,0.0001507102,0.0001693613,0.0002716688,0.0002166957,0.0001644394,0.0001546201,0.0003741937,0.0001721713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995612,"about_ca_system_score_gemma":0.0001107397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008939863,"about_ca_topic_score_gemma":0.0007852123,"domain_scores_codex":[0.9998338,0.00004600241,0.00001283106,0.00003838334,0.00003312577,0.00003574228],"domain_scores_gemma":[0.9995089,0.0001306276,0.0001458453,0.0000352511,0.00005756134,0.0001219117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001471912,0.0001828033,0.9806645,0.00001166374,0.00007703115,0.0004119642,0.0001155543,0.00007025851,0.01225412,0.00001210829,0.0001256496,0.004602558],"study_design_scores_gemma":[0.0000262329,0.0004377779,0.9972621,0.00000186218,0.00003168813,0.001097675,0.00005104885,0.0001651896,0.000694826,0.00001162468,0.0002167602,0.000003267841],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997485,0.0001028021,0.00003860274,0.00001161024,0.000001529036,0.000001244861,0.00002602868,0.000001358685,0.00006830876],"genre_scores_gemma":[0.9996223,0.00004619035,0.00003868697,0.00001748631,0.000006169324,0.000002690907,0.0001277705,0.000001092532,0.0001375431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008939863,"threshold_uncertainty_score":0.002147555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008935299649229515,"score_gpt":0.2301296431065388,"score_spread":0.2211943434573093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}