{"id":"W2130552343","doi":"","title":"Rational approaches for engineering carbon-carbon bond forming enzymes","year":2012,"lang":"en","type":"article","venue":"DOAJ (DOAJ: Directory of Open Access Journals)","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Biocatalysis; Stereospecificity; Enzyme; Chemistry; Protein engineering; Carbon fibers; Rational design; Carbon–carbon bond; Substrate (aquarium); Mutagenesis; Substrate specificity; Active site; Organic chemistry; Combinatorial chemistry; Stereochemistry; Catalysis; Biochemistry; Nanotechnology; Reaction mechanism; Biology; Materials science; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007299384,0.0002141232,0.0003235539,0.000208244,0.00009470234,0.0002195131,0.0006466404,0.0001315249,0.00009732858],"category_scores_gemma":[0.0003016203,0.0002021576,0.0001596883,0.0002347992,0.00003666948,0.0001149461,0.0003078594,0.0001015344,4.494655e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003108395,"about_ca_system_score_gemma":0.00006549856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000367796,"about_ca_topic_score_gemma":0.000007647473,"domain_scores_codex":[0.9986809,0.00003663032,0.0004545054,0.0002739052,0.0002322128,0.0003217745],"domain_scores_gemma":[0.999025,0.00005786254,0.0003270037,0.0002870085,0.0001630223,0.0001400767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007637665,0.0001332409,0.08695948,0.00008390711,0.0001899725,3.295607e-7,0.00006781203,0.000752673,0.9059907,0.0003212154,0.003215228,0.002209073],"study_design_scores_gemma":[0.0003816317,0.00001478914,0.03438948,0.00005999771,0.00008009019,0.000007220372,0.00005416448,0.001789792,0.9459823,0.0001451964,0.01676462,0.0003307395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576432,0.03540252,0.004407428,0.0000368879,0.000384387,0.0004551068,0.00002533705,0.00001137707,0.001633811],"genre_scores_gemma":[0.9969979,0.001073319,0.0006959338,0.00005695387,0.0006183275,0.0001096208,0.0002020797,0.00004552743,0.0002003609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05257,"threshold_uncertainty_score":0.8243749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1705377094758029,"score_gpt":0.4549502465357909,"score_spread":0.284412537059988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}