{"id":"W2130558223","doi":"10.1189/jlb.0506350","title":"The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-κB activation, and TNF-α secretion in macrophages","year":2006,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Canadian Cancer Society","keywords":"Secretion; TLR4; Tumor necrosis factor alpha; Biology; NF-κB; Kinase; Inflammatory response; Inflammation; Cell biology; NFKB1; IκB kinase; Macrophage; Signal transduction; Immunology; Biochemistry; Gene; Transcription factor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002000952,0.0001602755,0.0003046686,0.0002265295,0.0002511346,0.00002145002,0.0002297411,0.0002572945,0.00003376306],"category_scores_gemma":[0.0005862939,0.00009361842,0.00008966447,0.0002093792,0.0003917067,0.0002298973,0.00006565271,0.0002890686,0.00001194007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001025962,"about_ca_system_score_gemma":0.0001435465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001104692,"about_ca_topic_score_gemma":0.00005069722,"domain_scores_codex":[0.9972093,0.001449022,0.0008922617,0.0001422286,0.00005857711,0.0002486593],"domain_scores_gemma":[0.9974541,0.001309586,0.0007554399,0.0002286957,0.0002395332,0.00001264887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006340138,0.00002844307,0.002205855,0.00000900937,0.00005843863,0.000002860891,0.0007119676,0.0001300283,0.9828495,0.002088582,0.0006348838,0.004940265],"study_design_scores_gemma":[0.001044933,0.0003424902,0.2449207,0.00005497911,0.00001434832,0.00009922071,0.0003137856,0.000006439919,0.7219363,0.002041241,0.02914542,0.00008016994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991786,0.003902029,0.0002291647,0.003415842,0.0003149401,0.000273685,0.000003092802,0.000009156308,0.00006610591],"genre_scores_gemma":[0.9988849,0.0003640871,0.00008132554,0.00008111018,0.00009426445,0.00001081034,0.00001542063,0.00001025613,0.0004578695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2609132,"threshold_uncertainty_score":0.3817649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006472245697552675,"score_gpt":0.2361232227577364,"score_spread":0.2296509770601838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}