{"id":"W2130559114","doi":"10.1002/chin.200436145","title":"Synthesis of Dialkyl 1,4‐Dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and Alkyl 1,4‐Dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates Possessing a C‐4 2,4‐Dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (Uracil) Substituent to Determine Calcium Channel Modulation Structure—Activity Relationships.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Alkyl; Medicinal chemistry; Chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857236,0.000290779,0.0002941007,0.0001850549,0.000181845,0.0001673269,0.0002799866,0.0002147419,0.002408048],"category_scores_gemma":[0.0002194303,0.0001665598,0.0001303721,0.0001907791,0.0001314904,0.0002364794,0.00015748,0.0002692413,0.0006650894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004345363,"about_ca_system_score_gemma":0.00061004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006997702,"about_ca_topic_score_gemma":0.002704925,"domain_scores_codex":[0.9998624,0.0000184322,0.0000154291,0.00003554662,0.0000326491,0.00003551443],"domain_scores_gemma":[0.9998765,0.00001400274,0.00003187657,0.00001707728,0.00002360179,0.00003702235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001969906,0.00005859602,0.000057991,0.0001374675,0.000009862641,0.00004550833,0.00001983574,0.000322801,0.9919499,0.0007190935,0.0001755226,0.006306468],"study_design_scores_gemma":[0.00004599659,0.0004969601,0.0005033475,0.000005237086,0.00001140203,0.0000838156,0.000004749115,0.0002670254,0.9914622,0.00005244601,0.007059347,0.000007514482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480029,0.009494011,0.01656912,0.0002300451,0.0002500546,0.0007497655,0.003494372,0.0002965336,0.02091317],"genre_scores_gemma":[0.9695627,0.00394875,0.01513795,0.0000844188,0.00002459451,0.0002378081,0.001726968,0.00005262529,0.009224148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002408048,"threshold_uncertainty_score":0.008055747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257699486722802,"score_gpt":0.2442452164260385,"score_spread":0.2184752677537583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}