{"id":"W2130559114","doi":"10.1002/chin.200436145","title":"Synthesis of Dialkyl 1,4‐Dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and Alkyl 1,4‐Dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates Possessing a C‐4 2,4‐Dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (Uracil) Substituent to Determine Calcium Channel Modulation Structure—Activity Relationships.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Alkyl; Medicinal chemistry; Chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004994887,0.001013572,0.001304275,0.0005852127,0.0005922323,0.0002520135,0.0006481841,0.0006582512,0.0003943161],"category_scores_gemma":[0.0014587,0.001012471,0.000387445,0.0007694558,0.0003556761,0.001015928,0.0003621661,0.0007043257,0.00002039941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004343358,"about_ca_system_score_gemma":0.0001911163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264515,"about_ca_topic_score_gemma":0.0000405083,"domain_scores_codex":[0.9954406,0.00001731945,0.001465173,0.001135651,0.0009503623,0.0009908779],"domain_scores_gemma":[0.9959578,0.0009353824,0.0009661376,0.001148819,0.000324667,0.0006671994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002653455,0.0002322903,0.001869547,0.0005027457,0.0002395936,0.00001603079,0.001151983,0.00096344,0.9331021,0.00009786411,0.00002612847,0.06153288],"study_design_scores_gemma":[0.00101844,0.00006757012,0.007535557,0.0005530894,0.0002543186,0.0000853625,0.0002079902,0.00437661,0.9835731,0.000526321,0.0007114676,0.001090124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873585,0.0003730313,0.0003224121,0.0006055962,0.0002501528,0.0004306145,0.0002374477,0.0003123619,0.01010986],"genre_scores_gemma":[0.997668,0.0001268304,0.0009703042,0.00007378922,0.0004845609,0.0001247199,0.0001607462,0.000151278,0.0002398268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06044275,"threshold_uncertainty_score":0.9992326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257699486722802,"score_gpt":0.2442452164260385,"score_spread":0.2184752677537583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}