{"id":"W2130561025","doi":"10.1091/mbc.e11-06-0553","title":"Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase","year":2012,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Biology; Golgi apparatus; Cell biology; Phosphatidylinositol; Endosome; Glucocerebrosidase; Sphingolipid; Glucocerebroside; Exocyst; Biochemistry; Kinase; Secretion; Enzyme; Intracellular; Exocytosis; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253032,0.0001928767,0.0003515777,0.00005251526,0.00008919015,0.000003927023,0.0004898328,0.0001183673,0.0001295784],"category_scores_gemma":[0.0002572345,0.0001084962,0.0004096685,0.0002328067,0.0006419788,0.00003480803,0.0002654506,0.0002384481,0.00001868851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004463704,"about_ca_system_score_gemma":0.0001686369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001825278,"about_ca_topic_score_gemma":0.000004279054,"domain_scores_codex":[0.9983178,0.0004073803,0.0003091077,0.0002205037,0.0003027194,0.0004425368],"domain_scores_gemma":[0.9985334,0.0001019629,0.0001966377,0.0008037354,0.0001702778,0.000193953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004416224,0.0005630715,0.323469,0.0001167449,0.0001184552,0.000008282253,0.00007155276,0.00001819863,0.6741252,0.000390288,0.0004318876,0.000245667],"study_design_scores_gemma":[0.00267493,0.0001193029,0.07625061,0.00005495266,0.0003019146,0.000008575302,0.00004819284,0.0001093396,0.9194585,0.0001348839,0.0007246027,0.0001141948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857822,0.01098217,0.0002284992,0.001110514,0.0002275857,0.0007402807,0.00005554437,0.00001349188,0.0008596827],"genre_scores_gemma":[0.9983506,0.00003103086,0.0001228059,0.0009009303,0.00006489035,0.00002593162,0.00001102529,0.00002634692,0.0004664557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2472184,"threshold_uncertainty_score":0.4424347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009577325086687117,"score_gpt":0.2698475600673322,"score_spread":0.2602702349806451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}