{"id":"W2130640131","doi":"10.1101/gr.5383506","title":"Reconstructing contiguous regions of an ancestral genome","year":2006,"lang":"en","type":"article","venue":"Genome Research","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":302,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institutes of Health; Howard Hughes Medical Institute; U.S. Public Health Service; Broad Institute; National Human Genome Research Institute","keywords":"Biology; Genome; Breakpoint; Human genome; Lineage (genetic); Chromosome; Genetics; Evolutionary biology; Ancestor; Most recent common ancestor; Sequence (biology); Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002852388,0.0002105791,0.0003116974,0.001404709,0.0004199136,0.0003878056,0.0003743066,0.0003849651,0.0009473171],"category_scores_gemma":[0.001387798,0.0003524309,0.0003537359,0.001062852,0.0002579634,0.0006391819,0.000432695,0.0004516541,0.0004034135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940295,"about_ca_system_score_gemma":0.0003911028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001470379,"about_ca_topic_score_gemma":0.002128685,"domain_scores_codex":[0.9998666,0.00003122599,0.00000669824,0.0000521607,0.00002945206,0.00001384777],"domain_scores_gemma":[0.9996451,0.0001832543,0.00005881178,0.00006447561,0.00002940215,0.00001888158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007017944,0.00011751,0.1103963,0.0005066385,0.0003147266,0.001534786,0.002284504,0.1166331,0.577588,0.03267067,0.0007562337,0.1564958],"study_design_scores_gemma":[0.0001267034,0.0006902188,0.2825623,0.0001729095,0.0007284256,0.006028269,0.001413269,0.4305758,0.1572956,0.0571227,0.06313122,0.0001526984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8952124,0.0009420354,0.1012763,0.00009068684,0.000009304301,0.000008056034,0.0005089975,0.0003061104,0.001646102],"genre_scores_gemma":[0.8933131,0.000789898,0.1030143,0.00002051651,0.00001417495,0.00001289266,0.002282701,0.00007390168,0.0004785232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470379,"threshold_uncertainty_score":0.003169119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06058883880245984,"score_gpt":0.3356076091649754,"score_spread":0.2750187703625155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}