{"id":"W2130643141","doi":"10.1096/fj.07-095398","title":"PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP <sup>+</sup> in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Cure Parkinson’s Trust","keywords":"Glial cell line-derived neurotrophic factor; MPTP; Neurotrophic factors; Substantia nigra; Dopaminergic; Neuroprotection; Neurodegeneration; Neuroscience; Parkinson's disease; Brain-derived neurotrophic factor; Chemistry; Pars compacta; Pharmacology; Dopamine; Endocrinology; Internal medicine; Medicine; Biology; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005864,0.0002814855,0.0002975155,0.0002207002,0.0003173689,0.0000722381,0.0003656437,0.00008327593,0.0000140642],"category_scores_gemma":[0.0003346606,0.0002149745,0.00006470309,0.0003265621,0.0003304551,0.00076492,0.0001470155,0.000846647,0.000001065433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004399595,"about_ca_system_score_gemma":0.0001950657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000476008,"about_ca_topic_score_gemma":0.00001262299,"domain_scores_codex":[0.9976092,0.0005986778,0.0004678229,0.0004594233,0.0004738464,0.0003910603],"domain_scores_gemma":[0.9989691,0.0001754521,0.0002821374,0.0002551094,0.0000336825,0.0002845112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003789696,0.0003493515,0.003838015,0.00001576064,0.00000478449,0.00005722976,0.0006775494,0.003398067,0.9908168,0.00001715705,0.000157692,0.0002885937],"study_design_scores_gemma":[0.003019805,0.0004389377,0.02517219,0.00009310315,0.00002770614,0.0002124472,0.00008587568,0.05725059,0.9130815,0.0001395867,0.00007337194,0.0004048647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983671,0.00006677294,0.00006451444,0.000597548,0.00005804033,0.0004014026,0.0004163106,0.00001462547,0.00001367985],"genre_scores_gemma":[0.9983087,0.0007076035,0.0000477907,0.0005645217,0.00004129,0.00001637343,0.000004429078,0.00003291394,0.0002763331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07773531,"threshold_uncertainty_score":0.8766405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04910353538867339,"score_gpt":0.2609427242056108,"score_spread":0.2118391888169374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}