{"id":"W2130694311","doi":"10.4049/jimmunol.1301221","title":"Complement Activation Associated with ADAMTS13 Deficiency in Human and Murine Thrombotic Microangiopathy","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Thrombotic microangiopathy; ADAMTS13; Von Willebrand factor; Platelet; Complement system; Thrombotic thrombocytopenic purpura; Alternative complement pathway; Chemistry; Internal medicine; Endothelium; Schistocyte; Endocrinology; Immunology; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005107386,0.0001363801,0.0003194498,0.0001781786,0.0001651824,0.00001236208,0.0002832386,0.00006742508,0.0006259108],"category_scores_gemma":[0.00007200616,0.00008369858,0.00003808291,0.0001376801,0.00026816,0.0001285269,0.0001003869,0.0002742154,0.00002561784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001027168,"about_ca_system_score_gemma":0.00004464169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003048866,"about_ca_topic_score_gemma":0.0001217087,"domain_scores_codex":[0.9985192,0.000542062,0.0005157162,0.00009576786,0.00004856684,0.0002787057],"domain_scores_gemma":[0.9988296,0.0002978721,0.0005276298,0.0001815443,0.0001512112,0.00001214216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001584849,0.0003564472,0.0339361,0.00001121592,0.0003371466,0.000004159244,0.001040532,0.00002798726,0.961731,0.0004856784,0.001213841,0.0006974355],"study_design_scores_gemma":[0.0031242,0.001220869,0.9742122,0.0001998194,0.00008765642,0.0003050287,0.002134352,0.000002650915,0.01774703,0.0006215866,0.0002113627,0.0001332709],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955729,0.003131308,0.00006739255,0.0005974575,0.0001235,0.0003239313,0.000003393639,0.00001049638,0.0001696402],"genre_scores_gemma":[0.9997275,0.00004673692,0.00001882856,0.00007087897,0.00001041866,0.000008892017,0.00001331774,0.00001009876,0.00009331304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9439839,"threshold_uncertainty_score":0.6853284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598695387225797,"score_gpt":0.2402866697176084,"score_spread":0.2242997158453504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}