{"id":"W2130699389","doi":"10.1124/jpet.107.133124","title":"Differential High-Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans Is Dependent upon Primary Structure and Is Influenced by Polymer Chain Length and Side-Chain Branching","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":297,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"National Institute of General Medical Sciences","keywords":"Glucan; Innate immune system; Biochemistry; Candida albicans; Yeast; Biology; Branching (polymer chemistry); Pattern recognition receptor; Polysaccharide; Receptor; Chemistry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006807337,0.0001627358,0.0002699759,0.00002433343,0.0001927137,0.00002296142,0.00008467214,0.00009329073,0.000217448],"category_scores_gemma":[0.000001666893,0.00006563943,0.00003539432,0.00005302023,0.0001278425,0.0001723267,0.00004250201,0.0002863185,1.237277e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002433614,"about_ca_system_score_gemma":0.00001547348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001121654,"about_ca_topic_score_gemma":0.00002469897,"domain_scores_codex":[0.9991857,0.00009514153,0.0002571061,0.0001520773,0.0001463952,0.0001635111],"domain_scores_gemma":[0.9994215,0.0001825614,0.0002691281,0.00001921006,0.00002997539,0.0000775824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00172062,0.0001079842,0.001533666,0.000009056565,0.0001565323,0.00001518224,0.001391355,0.000001191976,0.9888521,0.000003212618,0.00004003775,0.006169075],"study_design_scores_gemma":[0.001003373,0.0009797062,0.005896679,0.00002371973,0.0000843982,0.000889138,0.0005720771,0.00008853681,0.9901595,0.00002049297,0.0001438055,0.0001385555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948171,0.004207229,0.000002612375,0.0005544492,0.0002600259,0.00009267286,0.00005418709,0.000004874344,0.000006887792],"genre_scores_gemma":[0.9967391,0.0016499,0.0000328122,0.001427766,0.0001059026,9.896494e-7,0.000004247723,0.000001984114,0.00003723835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006030519,"threshold_uncertainty_score":0.2676698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375636074538055,"score_gpt":0.2549282889924602,"score_spread":0.2411719282470796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}