{"id":"W2130701697","doi":"10.1002/anie.200906644","title":"Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines","year":2010,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research","keywords":"Chitobiose; Chitinase; Chemistry; Trisaccharide; Chitin; Enzyme; Stereochemistry; Enzymatic hydrolysis; Oxazoline; Hydrolysis; Biochemistry; Combinatorial chemistry; Chitosan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017003,0.0003469721,0.000172439,0.0001193482,0.00007825045,0.0001811272,0.0002249886,0.0002457947,0.001331023],"category_scores_gemma":[0.0001329368,0.0001080381,0.0001528429,0.0001056578,0.0001867274,0.0001376353,0.0001556942,0.0004099217,0.0003276761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775135,"about_ca_system_score_gemma":0.0001972345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001325435,"about_ca_topic_score_gemma":0.001311998,"domain_scores_codex":[0.9999328,0.00001113282,0.000007104679,0.00001209246,0.00001827345,0.0000186366],"domain_scores_gemma":[0.9999479,0.00001032415,0.00001341211,0.000005093445,0.000008906242,0.00001431815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272547,0.00001273867,0.00005535807,0.0000830238,0.000004159694,0.00006700537,0.00001656054,0.0001372944,0.9969578,0.0001855431,0.00006461117,0.002288629],"study_design_scores_gemma":[0.00002779231,0.0003411382,0.0004108295,0.000003415933,0.000005489781,0.0001128408,0.000007201317,0.0004082579,0.9967086,0.00002598128,0.001944461,0.000003996434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734585,0.00872741,0.008293177,0.000387503,0.000107577,0.00008456391,0.0003473099,0.0001892077,0.008404822],"genre_scores_gemma":[0.9886003,0.00287213,0.003057934,0.00007042448,0.00001763625,0.00004589904,0.0002009752,0.0000132612,0.005121351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331023,"threshold_uncertainty_score":0.004452765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004623076211753661,"score_gpt":0.2379367797064252,"score_spread":0.2333137034946715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}