{"id":"W2130779618","doi":"10.1017/s0031182013002072","title":"Progress and prospects for targeting Hsp90 to treat fungal infections","year":2014,"lang":"en","type":"article","venue":"Parasitology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Hsp90; Drug resistance; Antifungal; Antifungal drug; Pathogen; Drug; Hsp90 inhibitor; Microbiology; Pharmacology; Heat shock protein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091839,0.0001048301,0.0001355796,0.00005510297,0.0001475834,0.00002051095,0.00008895237,0.0001363061,0.000005743836],"category_scores_gemma":[0.0004397145,0.0000983135,0.000033355,0.00006915103,0.00008318627,0.000002165486,0.00009064303,0.00006637037,0.00002113906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001030854,"about_ca_system_score_gemma":0.00003597731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230562,"about_ca_topic_score_gemma":0.00004595089,"domain_scores_codex":[0.9990521,0.00008219483,0.0001181176,0.0003433806,0.00005676426,0.0003474109],"domain_scores_gemma":[0.9995422,0.00003539832,0.0000211987,0.0001862157,0.00008267358,0.0001323129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002153197,0.0001385845,0.3502627,0.0001094801,0.00003916359,0.000003658498,0.00008653414,0.00002574013,0.6247402,0.00154975,0.004656353,0.01817256],"study_design_scores_gemma":[0.001484944,0.003951819,0.03712326,0.00001350592,0.00002395485,0.0001318968,0.00002926519,0.000420768,0.7594725,0.0004681011,0.196465,0.0004148534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875593,0.0002766902,0.009689877,0.000749819,0.00008592581,0.000737174,0.00000792948,0.00002052432,0.0008727188],"genre_scores_gemma":[0.9953641,0.00001097828,0.00324089,0.0001106964,0.0003320227,0.0005382894,0.00003779724,0.00001893876,0.0003462871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3131394,"threshold_uncertainty_score":0.4009108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123319682865295,"score_gpt":0.3380661630679085,"score_spread":0.3268329662392556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}