{"id":"W2130807253","doi":"10.1042/bj20071719","title":"The intact CFTR protein mediates ATPase rather than adenylate kinase activity","year":2008,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Adenylate kinase; ATP hydrolysis; Biochemistry; Mutant; Cyclic nucleotide-binding domain; Chloride channel; ATPase; Walker motifs; Cell biology; Biology; ATP-binding cassette transporter; Chemistry; Enzyme; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003915286,0.0001771854,0.0002388297,0.00005961141,0.0003956764,0.00006242653,0.0002420087,0.00009861359,0.0002294334],"category_scores_gemma":[0.001750882,0.0001004227,0.0001714079,0.000188125,0.0004213784,0.0001246009,0.0000971975,0.000894397,0.0001186183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547257,"about_ca_system_score_gemma":0.0002897525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001353314,"about_ca_topic_score_gemma":0.000002200986,"domain_scores_codex":[0.9981556,0.0001084552,0.000260874,0.0002125648,0.0007520855,0.0005104269],"domain_scores_gemma":[0.9986246,0.0002504656,0.0001210249,0.0002855425,0.0001685074,0.0005498987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001198907,0.0001669012,0.001593232,0.00002019995,0.00005734727,0.000442726,0.00005913119,2.330677e-7,0.9823766,0.00001007927,0.008782262,0.005292413],"study_design_scores_gemma":[0.001486987,0.0004006714,0.01462136,0.0001667249,0.00002280847,0.001882196,0.00004988227,0.00008019854,0.9668557,0.0002967612,0.01398148,0.0001552429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927236,0.002417059,0.0001257344,0.00397363,0.0001032163,0.0003282133,0.000006826629,0.00003703093,0.0002846954],"genre_scores_gemma":[0.9959358,0.0003204614,0.001509762,0.00007091602,0.0008160016,0.00002535996,0.000003494734,0.0000269018,0.001291319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01552088,"threshold_uncertainty_score":0.4095119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054873858152818,"score_gpt":0.2991222629565045,"score_spread":0.2785735243749763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}