{"id":"W2130807253","doi":"10.1042/bj20071719","title":"The intact CFTR protein mediates ATPase rather than adenylate kinase activity","year":2008,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Adenylate kinase; ATP hydrolysis; Biochemistry; Mutant; Cyclic nucleotide-binding domain; Chloride channel; ATPase; Walker motifs; Cell biology; Biology; ATP-binding cassette transporter; Chemistry; Enzyme; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002587691,0.0002478278,0.0003524096,0.0001078842,0.0001858965,0.0004245639,0.000242524,0.0005297021,0.0008187536],"category_scores_gemma":[0.0003767984,0.0001094135,0.0002316988,0.00009849994,0.0005192378,0.0005191831,0.000208157,0.0004710041,0.0005364085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004824851,"about_ca_system_score_gemma":0.0003442406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006474908,"about_ca_topic_score_gemma":0.0006549691,"domain_scores_codex":[0.9997285,0.00003609378,0.00002864652,0.00007146549,0.00008752093,0.00004783683],"domain_scores_gemma":[0.9998475,0.00004321603,0.00002028154,0.00002851612,0.00002732669,0.00003320089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003051332,0.00001048234,0.0002144872,0.00004566914,0.000003516062,0.00007136049,0.00001205565,0.00002410412,0.9976943,0.0004677234,0.00005274513,0.00137298],"study_design_scores_gemma":[0.00002480484,0.0002233017,0.005344397,0.0000160797,0.00001667273,0.001542562,0.00004484754,0.001035563,0.9794074,0.0003341723,0.01200001,0.00001013403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824937,0.005790422,0.007534588,0.0006545492,0.0001530873,0.00003650282,0.0003832155,0.0001087522,0.002845176],"genre_scores_gemma":[0.9940601,0.001046647,0.002747572,0.00007195073,0.00002034812,0.00001213544,0.0004551778,0.000009309869,0.001576603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008187536,"threshold_uncertainty_score":0.0035007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054873858152818,"score_gpt":0.2991222629565045,"score_spread":0.2785735243749763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}