{"id":"W2130822830","doi":"10.1084/jem.192.2.303","title":"Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":2213,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cytotoxic T cell; IL-2 receptor; CD28; Interleukin 21; Biology; CTLA-4; T cell; Immunology; Peripheral tolerance; Antigen-presenting cell; Antigen; T lymphocyte; TCIRG1; ZAP70; Immune tolerance; Cell biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001880192,0.0004858153,0.0002824851,0.0004036139,0.0001787412,0.0004101627,0.0003113241,0.0003047051,0.001025039],"category_scores_gemma":[0.0001062443,0.0001707863,0.0003085221,0.0001293282,0.0003151174,0.0002840656,0.0001867332,0.0006975353,0.0004308993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349722,"about_ca_system_score_gemma":0.00021941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003367983,"about_ca_topic_score_gemma":0.0004110991,"domain_scores_codex":[0.999706,0.00004414155,0.00002646018,0.00006089809,0.00006186771,0.0001006491],"domain_scores_gemma":[0.9998622,0.00001165896,0.0000401606,0.00003244009,0.00001452907,0.00003892321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008203316,0.00003767185,0.0001745184,0.00001244586,0.000004000176,0.00006745714,0.000009301644,0.00005968267,0.9982318,0.00009622824,0.00002960173,0.001195344],"study_design_scores_gemma":[0.00008497145,0.001335411,0.003916952,0.000008013368,0.00005419855,0.0009874535,0.00004066335,0.001774457,0.9878922,0.0001920214,0.003700665,0.00001294928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994076,0.001198625,0.002470565,0.0000598783,0.00005748959,0.00002953491,0.00008220871,0.0001926201,0.001833006],"genre_scores_gemma":[0.9957522,0.0004220826,0.001255978,0.00004691316,0.0000249132,0.00002519673,0.000160907,0.00001868498,0.002293147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025039,"threshold_uncertainty_score":0.003429115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009181289255423462,"score_gpt":0.2335886930219979,"score_spread":0.2244074037665744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}