{"id":"W2130827011","doi":"10.1172/jci16510","title":"Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":406,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"TLR4; Bone marrow; Intravital microscopy; Endothelium; Immunology; Lipopolysaccharide; Inflammation; Pulmonary sequestration; Microcirculation; Biology; Medicine; Pathology; Lung; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003074771,0.0001498878,0.0003762511,0.0001413167,0.0001296936,0.00003602498,0.0002124459,0.0003724372,0.0001637855],"category_scores_gemma":[0.002164251,0.0001065662,0.0002027414,0.0002075747,0.0002111843,0.0004005783,0.0000189326,0.0007953434,0.0001524526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006681127,"about_ca_system_score_gemma":0.0004367541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003881814,"about_ca_topic_score_gemma":0.00001312721,"domain_scores_codex":[0.9959199,0.001930171,0.001684393,0.0001679667,0.0001042262,0.0001933336],"domain_scores_gemma":[0.9977874,0.0006120307,0.001064741,0.0002271382,0.0002644701,0.00004426646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003684006,0.00006897563,0.002654225,0.0000085698,0.00007768416,0.000005123628,0.001366444,0.00002191613,0.989791,0.001729006,0.002032636,0.001876007],"study_design_scores_gemma":[0.00240016,0.0007884945,0.01813799,0.0001184693,0.00005694054,0.00007931093,0.0003443254,0.00004013658,0.9525432,0.004692109,0.02062915,0.0001697365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911478,0.0004654568,0.0001517148,0.006272324,0.001367304,0.0002048864,7.855264e-7,0.00001204858,0.0003776487],"genre_scores_gemma":[0.9969339,0.0003415247,0.0004598632,0.001816534,0.0001242374,0.000006878229,0.00001427951,0.00001359188,0.000289231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03724784,"threshold_uncertainty_score":0.4345642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04664398978921872,"score_gpt":0.324553986857845,"score_spread":0.2779099970686263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}