{"id":"W2130828922","doi":"10.2174/187152712800672490","title":"Janus Molecule I: Dichotomous Effects of COMT in Neuropathic vs Nociceptive Pain Modalities","year":2012,"lang":"en","type":"review","venue":"CNS & Neurological Disorders - Drug Targets","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke","keywords":"Neuroscience; Nociception; Neuropathic pain; Adrenergic receptor; Adrenergic; Receptor; Chronic pain; Stimulation; Medicine; Norepinephrine; Analgesic; Psychology; Internal medicine; Pharmacology; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172486,0.0008066219,0.001267328,0.001822139,0.0002537821,0.0008370127,0.0006024357,0.000704154,0.002521443],"category_scores_gemma":[0.0002503049,0.0002254617,0.0003715804,0.001699073,0.0004700132,0.00102511,0.0005839162,0.001150361,0.001608403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003729343,"about_ca_system_score_gemma":0.0004706611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004681636,"about_ca_topic_score_gemma":0.0009545083,"domain_scores_codex":[0.9999114,0.00001275408,0.00001572006,0.00002027089,0.00003048295,0.000009271947],"domain_scores_gemma":[0.9999151,0.0000350376,0.00001795486,0.000002929854,0.0000182586,0.00001066126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000139511,0.00006424852,0.0002142216,0.01822444,0.00009972857,0.0004089686,0.00008998047,0.000226533,0.008721332,0.004032401,0.01151846,0.9562602],"study_design_scores_gemma":[0.00003951977,0.0001620828,0.002223067,0.002993245,0.0001671539,0.003723309,0.0001244442,0.0001333631,0.003541145,0.003315174,0.9835435,0.00003411863],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002859056,0.9981243,0.0001466087,0.0001468172,0.0001267825,0.000004826637,0.0000227825,0.000007929092,0.001133923],"genre_scores_gemma":[0.00170695,0.99675,0.000258931,0.0001299422,0.0001498849,0.000007924249,0.0000403752,0.000001987165,0.0009540787],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002521443,"threshold_uncertainty_score":0.00843513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02000286827701907,"score_gpt":0.2803542700231856,"score_spread":0.2603514017461666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}