{"id":"W2130830305","doi":"10.1085/jgp.200509439","title":"Identification of a Disulfide Bridge Linking the Fourth and the Seventh Extracellular Loops of the Na+/Glucose Cotransporter","year":2006,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mutant; Cysteine; Biophysics; Cotransporter; Chemistry; Extracellular; Biochemistry; Xenopus; Patch clamp; Voltage clamp; Stereochemistry; Membrane potential; Biology; Receptor; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006815803,0.00009572267,0.0001746347,0.00001674278,0.000117683,0.000005244908,0.0003163815,0.0000698064,0.000003730943],"category_scores_gemma":[0.000008922406,0.00003918251,0.0001761216,0.00006975664,0.0004481571,0.000005915296,0.00002698554,0.00012571,1.931268e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003932174,"about_ca_system_score_gemma":0.00003433595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004899304,"about_ca_topic_score_gemma":0.00003341139,"domain_scores_codex":[0.998944,0.0002319091,0.0004881962,0.00008240512,0.0001438145,0.0001096427],"domain_scores_gemma":[0.9989049,0.00003360574,0.0006427797,0.0002680156,0.0001375155,0.00001315061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000397522,0.00003346426,0.0005340666,0.00001471508,0.00006175217,3.010309e-7,0.0002054681,0.004653681,0.9932561,0.0004422656,0.00008309686,0.000317566],"study_design_scores_gemma":[0.0008747786,0.00009091489,0.246314,0.00002091177,0.0001571171,0.00004578093,0.00006778415,0.0006747107,0.7480322,0.003302923,0.000357771,0.0000611223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936619,0.002399534,0.002842275,0.0007536909,0.0001781945,0.0001435589,0.000008489463,9.298128e-7,0.00001136134],"genre_scores_gemma":[0.9988269,0.0004405751,0.0000174627,0.00008228108,0.0003976016,0.000001865041,0.00001796811,0.00000894596,0.0002064129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2457799,"threshold_uncertainty_score":0.1651253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005329438860054993,"score_gpt":0.205287120623615,"score_spread":0.19995768176356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}