{"id":"W2130839195","doi":"10.1038/nrd1657","title":"The evolving role of natural products in drug discovery","year":2005,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":2555,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Drug discovery; Natural product; Natural (archaeology); Pharmaceutical industry; Risk analysis (engineering); Natural Product Research; Biochemical engineering; Lead (geology); Business; Data science; Computer science; Pharmacology; Engineering; Medicine; Chemistry; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001972468,0.001326793,0.00236884,0.002998892,0.0005340704,0.002055217,0.001697738,0.002122576,0.003997408],"category_scores_gemma":[0.002116152,0.0004618528,0.0006053564,0.004545094,0.002279658,0.003985087,0.001273274,0.003796207,0.002890781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001526764,"about_ca_system_score_gemma":0.001873828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320392,"about_ca_topic_score_gemma":0.00301999,"domain_scores_codex":[0.9994113,0.0001183615,0.00005560768,0.00006980981,0.0003075422,0.00003734359],"domain_scores_gemma":[0.9983456,0.0009735401,0.0001347329,0.00005781149,0.0003499351,0.0001383598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001178474,0.00006891532,0.0001443078,0.01082669,0.00009829661,0.000237223,0.00006717312,0.0005474467,0.002209411,0.01203735,0.05065575,0.9229897],"study_design_scores_gemma":[0.00002781347,0.00005130078,0.0002231379,0.001183652,0.00004936334,0.0005844714,0.00004173191,0.0001022499,0.000284836,0.005267801,0.992169,0.00001456176],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006288429,0.9968771,0.0004551371,0.0005797284,0.0006856958,0.00000431833,0.000008869058,0.00001190448,0.001314323],"genre_scores_gemma":[0.0004583176,0.997177,0.0006062597,0.0005000465,0.0005563163,0.000005361207,0.00001547299,0.000001841385,0.0006794389],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003997408,"threshold_uncertainty_score":0.01337266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522389349587295,"score_gpt":0.3010342389402848,"score_spread":0.2858103454444119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}