{"id":"W2130891215","doi":"10.1093/hmg/ddl002","title":"A role for Brca1 in chromosome end maintenance","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Telomere; Biology; Chromosomal translocation; Carcinogenesis; Phenotype; Genetics; Cancer research; DNA damage; DNA repair; Genome instability; Chromosome; Cell biology; DNA; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012385,0.0001831906,0.0002772895,0.0001331076,0.00006052946,0.00002165812,0.0001328797,0.0001054179,0.00006521085],"category_scores_gemma":[0.00002701084,0.0001867946,0.0001125229,0.0001705473,0.00009545968,0.00001848563,0.00003373714,0.0001278961,0.00002071528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007018953,"about_ca_system_score_gemma":0.00006695643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001131392,"about_ca_topic_score_gemma":0.0002216774,"domain_scores_codex":[0.9986522,0.00002350031,0.0003162108,0.0003507235,0.0002260124,0.0004313174],"domain_scores_gemma":[0.9993396,0.00001781051,0.00006295704,0.0004022447,0.00008456468,0.00009287104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004693653,0.0002422184,0.008424436,0.00009842279,0.00001913748,0.0002447274,0.0001416117,0.0001280864,0.983299,0.003388488,0.0009613658,0.003005528],"study_design_scores_gemma":[0.006726638,0.0008570259,0.6432192,0.0002847424,0.0001329838,0.000173081,0.0001694224,0.001683957,0.2773072,0.01342161,0.05522659,0.0007975766],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919332,0.002652016,0.001681076,0.0001919283,0.00005605679,0.0005807308,0.00001489065,0.00004830081,0.002841857],"genre_scores_gemma":[0.9938483,0.00004880901,0.004171599,0.0005386038,0.0001715536,0.0000551242,0.00007817138,0.00004904074,0.001038859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7059919,"threshold_uncertainty_score":0.7617263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128635892151681,"score_gpt":0.2589081065824927,"score_spread":0.2476217476609759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}