{"id":"W2130894248","doi":"10.1128/jvi.01869-08","title":"Reovirus FAST Protein Transmembrane Domains Function in a Modular, Primary Sequence-Independent Manner To Mediate Cell-Cell Membrane Fusion","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation","keywords":"Biology; Transmembrane protein; Membrane protein; Vesicle-associated membrane protein 8; Fusion protein; Transmembrane domain; Cell biology; Membrane topology; Protein domain; Conserved sequence; Peptide sequence; Peripheral membrane protein; Integral membrane protein; Biochemistry; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004460388,0.0002042138,0.0003331832,0.0002397833,0.00004004717,0.00001486152,0.0002939382,0.0003049369,0.00004686596],"category_scores_gemma":[0.00001642053,0.0001759913,0.0001607387,0.0001264087,0.00003568052,0.00001759816,0.00004191623,0.0003306601,0.00002854547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005104902,"about_ca_system_score_gemma":0.0001204895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001960145,"about_ca_topic_score_gemma":0.00006865305,"domain_scores_codex":[0.9983838,0.0001573891,0.0005690285,0.0003036658,0.0002492184,0.0003369254],"domain_scores_gemma":[0.9992332,0.000007914499,0.0002492338,0.0002394751,0.0001147305,0.0001554066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002188202,0.0002819575,0.0001277035,0.00002289793,0.00002073165,0.0001738142,0.0001191518,0.001838607,0.9919087,0.000004926901,0.0001747319,0.003138572],"study_design_scores_gemma":[0.002471767,0.006246794,0.007503997,0.00003749382,0.00004140603,0.0001971973,0.00007112812,0.00006375939,0.9800461,0.0001760575,0.002901877,0.0002424325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950595,0.0006147521,0.00202289,0.0009728186,0.0002565239,0.00025803,0.0000077227,0.000004636729,0.0008031559],"genre_scores_gemma":[0.9961032,0.0004988447,0.0004487408,0.002098134,0.0003087923,0.000006726193,0.00002324414,0.00001595487,0.0004963435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01186261,"threshold_uncertainty_score":0.7176716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00858875775891771,"score_gpt":0.230232412913765,"score_spread":0.2216436551548473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}