{"id":"W2130894248","doi":"10.1128/jvi.01869-08","title":"Reovirus FAST Protein Transmembrane Domains Function in a Modular, Primary Sequence-Independent Manner To Mediate Cell-Cell Membrane Fusion","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation","keywords":"Biology; Transmembrane protein; Membrane protein; Vesicle-associated membrane protein 8; Fusion protein; Transmembrane domain; Cell biology; Membrane topology; Protein domain; Conserved sequence; Peptide sequence; Peripheral membrane protein; Integral membrane protein; Biochemistry; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002361925,0.0007007084,0.0002403879,0.0002595804,0.0001841587,0.0003980207,0.0003111004,0.0004012059,0.001039548],"category_scores_gemma":[0.0002248955,0.0001902605,0.0005365714,0.0001477698,0.0002785547,0.0004220053,0.0004621289,0.0004338175,0.0009761322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004950169,"about_ca_system_score_gemma":0.0002336895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004087172,"about_ca_topic_score_gemma":0.0004967976,"domain_scores_codex":[0.9998071,0.00003163488,0.00001276072,0.00003445473,0.00005516826,0.0000589489],"domain_scores_gemma":[0.9998506,0.00002580476,0.0000401642,0.00002538423,0.00002261631,0.00003539148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001159249,0.0000160981,0.0003965969,0.00004992473,0.00001473008,0.0001728681,0.00001662785,0.0001704687,0.9950086,0.00079762,0.0001147294,0.003125834],"study_design_scores_gemma":[0.00008527256,0.0004797158,0.01000609,0.00002305434,0.00004017464,0.002405987,0.00006518389,0.003542569,0.9640136,0.0006274053,0.01868357,0.00002726239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692817,0.00260393,0.02307095,0.0001471117,0.00007033184,0.00009424715,0.000655132,0.0003608488,0.003715785],"genre_scores_gemma":[0.9849279,0.001022664,0.009029371,0.00006522185,0.00001591985,0.00005383655,0.001040181,0.00003978815,0.003805105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039548,"threshold_uncertainty_score":0.003591597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00858875775891771,"score_gpt":0.230232412913765,"score_spread":0.2216436551548473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}