{"id":"W2130994570","doi":"10.1016/j.bmcl.2008.12.066","title":"Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Moiety; Structural isomer; Stereochemistry; Arachidonate 5-lipoxygenase; Chemical synthesis; Arachidonic acid; Enzyme; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970969,0.0004181835,0.0002828748,0.0002719404,0.0001941941,0.0001624456,0.0003778313,0.000337906,0.002054862],"category_scores_gemma":[0.0001451124,0.0001711864,0.0002393416,0.0002465768,0.0001414263,0.0003336832,0.0002169512,0.0003003253,0.0005387243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993844,"about_ca_system_score_gemma":0.0004282176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004339284,"about_ca_topic_score_gemma":0.0009988782,"domain_scores_codex":[0.999891,0.00001772871,0.00001132508,0.00001343287,0.0000215003,0.00004503982],"domain_scores_gemma":[0.9999229,0.000007952074,0.00003078791,0.000007272458,0.00001134351,0.00001978466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004657111,0.0001404062,0.0002184886,0.0002344803,0.00002371148,0.0004186386,0.00006805205,0.0007399086,0.9796059,0.001817426,0.0004606967,0.01580656],"study_design_scores_gemma":[0.0001610076,0.001931769,0.002119008,0.00001588249,0.00005093123,0.0005356823,0.00003286023,0.0009127872,0.9798519,0.000183,0.01418045,0.00002471247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603371,0.006385678,0.01600633,0.0004549405,0.0002464314,0.0002497149,0.001318427,0.0002541551,0.01474709],"genre_scores_gemma":[0.985404,0.003393438,0.006756411,0.00009961498,0.00004455418,0.00009161895,0.0005436729,0.00001528011,0.003651433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002054862,"threshold_uncertainty_score":0.006874204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907890944656418,"score_gpt":0.2429043826227847,"score_spread":0.2238254731762205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}