{"id":"W2131019078","doi":"10.1093/glycob/cwn041","title":"Covalent inhibitors of glycosidases and their applications in biochemistry and biology","year":2008,"lang":"en","type":"review","venue":"Glycobiology","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Covalent bond; Biochemistry; Enzyme; Residue (chemistry); Chemistry; Structural biology; Chemical biology; In vivo; Computational biology; Biology; Organic chemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006733162,0.0004751357,0.001659837,0.0001050192,0.00005262831,0.000005913092,0.0002328809,0.001037526,0.00008523581],"category_scores_gemma":[0.00009680756,0.0003691637,0.0002167146,0.0001734634,0.0007510797,0.00001505087,0.0002113679,0.0003633108,0.000002245055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006040267,"about_ca_system_score_gemma":0.0001412568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003712323,"about_ca_topic_score_gemma":0.000003850874,"domain_scores_codex":[0.9982613,0.00005132002,0.0007095604,0.0006555901,0.0000270662,0.0002951342],"domain_scores_gemma":[0.9982807,0.0007643944,0.0003785831,0.0004551293,0.00003028171,0.00009088348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003177024,0.0002367935,0.000844966,0.03697276,0.0004018845,0.00001598503,0.0001475567,1.065493e-7,0.07678467,0.0003119256,0.00024674,0.8840048],"study_design_scores_gemma":[0.0002408015,0.00001864125,0.000001833978,0.001764324,0.0001180473,0.0004368668,0.0001122626,8.197509e-7,0.0682687,0.000191538,0.9283742,0.0004719654],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01715259,0.9807005,0.000003907604,0.000008789993,0.00003327336,0.0001611353,0.0006101597,0.00002935149,0.001300322],"genre_scores_gemma":[0.01498488,0.9838329,0.00002638259,0.000005199205,0.0001475123,0.0002194075,0.0006661298,0.00002945837,0.00008814936],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9281275,"threshold_uncertainty_score":0.999876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03580807588741771,"score_gpt":0.2908192608275774,"score_spread":0.2550111849401597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}