{"id":"W2131031137","doi":"10.4049/jimmunol.0901288","title":"Transgenic Expression of Hsc70 in Pancreatic Islets Enhances Autoimmune Diabetes in Response to β Cell Damage","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Biology; Inflammation; Proinflammatory cytokine; Autoimmunity; Immune system; Pancreatic islets; Programmed cell death; Genetically modified mouse; Islet; Transgene; Immunology; Apoptosis; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005109,0.0003869121,0.0002399143,0.000354191,0.0001067073,0.0004034852,0.0001166376,0.0002725743,0.001050282],"category_scores_gemma":[0.000149531,0.0001837022,0.0002390048,0.000189395,0.0003250681,0.0002110047,0.0002182708,0.0007673535,0.0002229055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381529,"about_ca_system_score_gemma":0.0001352573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002104496,"about_ca_topic_score_gemma":0.0003579038,"domain_scores_codex":[0.9997885,0.00003735131,0.00002478187,0.00003854924,0.00005247754,0.00005845756],"domain_scores_gemma":[0.9997234,0.00003609057,0.00009264958,0.00002742145,0.0000150935,0.0001053293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169977,0.00002786566,0.0001142959,0.00001154826,0.000003385346,0.00003790007,0.000009154708,0.00002503158,0.9991991,0.0000294173,0.000009786487,0.0004156002],"study_design_scores_gemma":[0.00005579519,0.001085817,0.007527963,0.00001267191,0.00004783073,0.0005002758,0.00004792245,0.000727121,0.9884575,0.00009944216,0.001428761,0.000008784727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980173,0.00052749,0.0007268451,0.00005060039,0.00001909754,0.00001229585,0.00009837782,0.00006136742,0.0004866571],"genre_scores_gemma":[0.9969733,0.0005353877,0.0008967472,0.00005434937,0.00001509783,0.00001783221,0.0002350883,0.0000266809,0.001245583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050282,"threshold_uncertainty_score":0.003513575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008444160374071558,"score_gpt":0.2718052416849126,"score_spread":0.263361081310841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}