{"id":"W2131078522","doi":"10.1128/aac.02719-13","title":"Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Integrase; ADME; Integrase inhibitor; Potency; Chemistry; Pharmacology; Allosteric regulation; Biology; Pharmacokinetics; Biochemistry; Enzyme; In vitro; Virus; Virology; DNA; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003761279,0.0006481335,0.0005894273,0.0003767899,0.0001787793,0.0004949381,0.0004473911,0.0003464044,0.002401734],"category_scores_gemma":[0.0002828972,0.0002178782,0.0002878327,0.0002786126,0.0001812317,0.0002722974,0.0001274474,0.001036029,0.0008472319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003087046,"about_ca_system_score_gemma":0.0005204602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007120771,"about_ca_topic_score_gemma":0.001470099,"domain_scores_codex":[0.9998999,0.00003339536,0.000006350523,0.00001266211,0.00002353276,0.00002422089],"domain_scores_gemma":[0.9998586,0.00001487806,0.00003110376,0.00001402927,0.00002743869,0.00005397094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009844732,0.01117413,0.002040934,0.0004579425,0.0002269638,0.0004042164,0.0001210331,0.004232148,0.8713297,0.0007401174,0.003645655,0.09578238],"study_design_scores_gemma":[0.005966574,0.3422513,0.0256239,0.0001058993,0.000710245,0.002980824,0.0001309792,0.007964022,0.5801461,0.0006417193,0.03339258,0.00008577863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756646,0.008216921,0.003712582,0.0003960454,0.00008112242,0.0006647165,0.00226999,0.0004249449,0.008569184],"genre_scores_gemma":[0.98247,0.005505958,0.002291534,0.0002766933,0.0000398562,0.0002736286,0.003543401,0.00004959618,0.00554932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002401734,"threshold_uncertainty_score":0.008034647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491648844414936,"score_gpt":0.2730193150283184,"score_spread":0.2581028265841691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}