{"id":"W2131078522","doi":"10.1128/aac.02719-13","title":"Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Integrase; ADME; Integrase inhibitor; Potency; Chemistry; Pharmacology; Allosteric regulation; Biology; Pharmacokinetics; Biochemistry; Enzyme; In vitro; Virus; Virology; DNA; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590041,0.000231605,0.0004518481,0.00009428686,0.00006104158,0.00002097615,0.00007545147,0.0001201252,0.0002234997],"category_scores_gemma":[0.00002267433,0.0001718264,0.0001344171,0.0001290881,0.000126368,0.00006264896,0.00004298945,0.0001281371,0.0001044438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002374026,"about_ca_system_score_gemma":0.0000634832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002219547,"about_ca_topic_score_gemma":0.000004852964,"domain_scores_codex":[0.9988431,0.00001394309,0.0003926403,0.0003483123,0.000155428,0.0002465898],"domain_scores_gemma":[0.9993735,0.0000399243,0.0001272366,0.0002440941,0.00007355838,0.0001417064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001822618,0.005266609,0.4774007,0.0006407626,0.001132066,0.00002953387,0.004606518,8.838572e-7,0.1519052,0.0001110442,0.3165839,0.04050008],"study_design_scores_gemma":[0.03429569,0.0009413349,0.2195542,0.001463681,0.0005713136,0.0001233338,0.000187481,0.001755317,0.4603943,0.00002756834,0.2797219,0.0009639346],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911454,0.00001110568,0.0005932888,0.005994063,0.0001158374,0.0004974001,0.00004763249,0.00003421527,0.001561111],"genre_scores_gemma":[0.9792094,0.0001969364,0.005226901,0.002960503,0.0002062434,0.00001192926,0.0001998861,0.00003939403,0.01194884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.308489,"threshold_uncertainty_score":0.7006876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491648844414936,"score_gpt":0.2730193150283184,"score_spread":0.2581028265841691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}