{"id":"W2131086685","doi":"10.1210/en.2007-0361","title":"Synergistic Effects of Epidermal Growth Factor and Hepatocyte Growth Factor on Human Ovarian Cancer Cell Invasion and Migration: Role of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase","year":2007,"lang":"en","type":"article","venue":"Endocrinology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Hepatocyte growth factor; Epidermal growth factor; MAPK/ERK pathway; Cancer research; Protein kinase B; Ovarian cancer; Biology; Growth factor; Autocrine signalling; Kinase; Protein kinase A; Signal transduction; Cell biology; Endocrinology; Internal medicine; Cancer; Medicine; Cell culture; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008215218,0.0003238723,0.0004052989,0.0001170501,0.00009919519,0.00001230653,0.0001268538,0.0002624942,0.00004068285],"category_scores_gemma":[0.0001049267,0.000312354,0.00005855374,0.00009927189,0.0003111022,0.00001458817,0.0001201073,0.0001675268,5.096783e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004071383,"about_ca_system_score_gemma":0.00006256608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001284206,"about_ca_topic_score_gemma":0.0002491884,"domain_scores_codex":[0.9982572,0.0001682079,0.0004175584,0.0005799772,0.0001535562,0.0004235523],"domain_scores_gemma":[0.9990235,0.0001115681,0.0002966515,0.0002642953,0.0001507016,0.0001532569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004571013,0.000114766,0.01159223,0.0003445956,0.0001027651,0.00005386278,0.0001816518,0.000004346808,0.9854686,0.0003169191,0.00001628114,0.001346895],"study_design_scores_gemma":[0.001751981,0.001173761,0.0215763,0.0001055827,0.00005020881,0.00001340208,0.00003403646,0.00003562208,0.9746324,0.0001167944,0.000227437,0.0002824549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899058,0.00892482,0.0003019734,0.00004269668,0.0001054178,0.0005956356,0.00006303753,0.0000195047,0.00004110885],"genre_scores_gemma":[0.9991046,0.0003516394,0.0001729488,0.00003262359,0.0001057755,0.00004970228,0.00005205611,0.00004002271,0.0000906167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01083616,"threshold_uncertainty_score":0.9999328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289217148316396,"score_gpt":0.2511293095207689,"score_spread":0.2382371380376049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}