{"id":"W2131169418","doi":"10.1186/s13195-015-0152-z","title":"Predicting Alzheimer's disease development: a comparison of cognitive criteria and associated neuroimaging biomarkers","year":2015,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; Université Laval; Heart and Stroke Foundation; Sunnybrook Health Science Centre","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Linda C. Campbell Foundation; Eisai; University of California, San Diego; University of Toronto; H. Lundbeck A/S; Northern California Institute for Research and Education; Canadian Vascular Network; Servier; Pfizer; Biogen; Sunnybrook Research Institute; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; Heart and Stroke Foundation of Canada; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; IXICO; Fonds de Recherche du Québec - Santé; L'Oreal USA; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Geriatric psychiatry; Neuroimaging; Neurology; Disease; Cognition; Cognitive aging; Medicine; Dementia; Psychology; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002854151,0.0002531609,0.0004611902,0.000553301,0.000286363,0.0001157247,0.0001976321,0.00007884301,0.0001775746],"category_scores_gemma":[0.001167549,0.0002228287,0.00008255704,0.0007960849,0.0006568905,0.0002625162,0.000247554,0.0005232774,0.00003147113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004764934,"about_ca_system_score_gemma":0.0008830946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001647886,"about_ca_topic_score_gemma":0.00001062812,"domain_scores_codex":[0.9954115,0.0008672922,0.0005049105,0.0005584782,0.001795389,0.0008624765],"domain_scores_gemma":[0.996251,0.0006975607,0.0001251028,0.0002526841,0.001704723,0.0009689063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003478938,0.001141984,0.8638026,0.00002144282,0.003369273,0.0000781877,0.00403755,1.369579e-7,0.002377732,0.000009105526,0.001470337,0.1202127],"study_design_scores_gemma":[0.008388365,0.001794604,0.9538238,0.0005512137,0.0005131042,0.00001212435,0.0049183,0.00210327,0.02505628,0.0001444652,0.002387468,0.0003069981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657515,0.02857366,0.00003927,0.0008954248,0.00007404981,0.001595578,0.00002424536,0.00007412696,0.002972205],"genre_scores_gemma":[0.9988024,0.0003438861,0.0001971108,0.0001709683,0.00006606433,0.0001543601,0.000132279,0.00005371189,0.00007923366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1199057,"threshold_uncertainty_score":0.9086689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2039341602275118,"score_gpt":0.4546558526369192,"score_spread":0.2507216924094074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}