{"id":"W2131221639","doi":"10.1128/jvi.78.5.2242-2246.2004","title":"Genetic Basis of Hypersusceptibility to Protease Inhibitors and Low Replicative Capacity of Human Immunodeficiency Virus Type 1 Strains in Primary Infection","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of British Columbia","funders":"National Center for Research Resources; Fogarty International Center; Center for AIDS Research, University of Washington; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Biology; Ritonavir; Virology; Amprenavir; Virus; Reverse transcriptase; Protease; Genotype; Mutation; Lentivirus; Integrase; Genetics; Human immunodeficiency virus (HIV); HIV-1 protease; Viral load; Enzyme; Viral disease; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006212628,0.0003079943,0.0002788273,0.0005894265,0.0001756881,0.0003459322,0.0001915301,0.0002661285,0.0007364868],"category_scores_gemma":[0.003230511,0.000157157,0.0002553994,0.0003240488,0.0004402131,0.000139839,0.0002276801,0.0003337258,0.0001275696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772394,"about_ca_system_score_gemma":0.0001021608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111452,"about_ca_topic_score_gemma":0.00109745,"domain_scores_codex":[0.9994406,0.0001979443,0.00005477453,0.0001232021,0.00009832354,0.00008518003],"domain_scores_gemma":[0.9979922,0.0009520808,0.0005923413,0.0001144537,0.0001129909,0.0002359071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000282936,0.00003714439,0.9860714,0.00001155114,0.00006709457,0.0005012422,0.00007826844,0.0004945977,0.009224766,0.000025341,0.00004110886,0.003164441],"study_design_scores_gemma":[0.00000572873,0.0002012338,0.9930258,0.000005212443,0.00003101622,0.002182204,0.00007789012,0.002572831,0.001769716,0.00006556122,0.00005772051,0.000005140459],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997457,0.00006233081,0.00008805819,0.000004798165,7.441511e-7,0.000001989857,0.00002536315,0.00000210713,0.00006888602],"genre_scores_gemma":[0.9998353,0.00001580951,0.00007747649,0.000002820814,0.000001494772,8.004952e-7,0.00004897732,8.006891e-7,0.00001645574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111452,"threshold_uncertainty_score":0.003285587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819946504420863,"score_gpt":0.2762408370894616,"score_spread":0.258041372045253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}