{"id":"W2131238799","doi":"10.1124/jpet.102.039404","title":"Inflammatory Cytokines, but Not Bile Acids, Regulate Expression of Murine Hepatic Anion Transporters in Endotoxemia","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Multidrug resistance-associated protein 2; Organic anion-transporting polypeptide; Bile acid; Organic anion transporter 1; In vivo; Cholestasis; Bile Salt Export Pump; Chemistry; Efflux; Lipopolysaccharide; Tumor necrosis factor alpha; Taurocholic acid; Hepatocyte; Chenodeoxycholic acid; In vitro; Endocrinology; Pharmacology; Internal medicine; Transporter; Biology; Biochemistry; ATP-binding cassette transporter; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002707302,0.0004004814,0.0004027487,0.0004433021,0.0002392533,0.0005210921,0.0001224822,0.0003267643,0.0009825189],"category_scores_gemma":[0.0002810932,0.0002964948,0.0002715051,0.0002342461,0.0004926994,0.0004238486,0.0002482121,0.0007116962,0.0003431506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000371819,"about_ca_system_score_gemma":0.0001902467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002684637,"about_ca_topic_score_gemma":0.0004299658,"domain_scores_codex":[0.9996173,0.00008937254,0.0000375106,0.00004535045,0.00007274291,0.0001376671],"domain_scores_gemma":[0.9996448,0.00005495416,0.0001348205,0.00003525283,0.00004734811,0.00008290855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00147948,0.00004187264,0.000471803,0.00002227934,0.000003588564,0.00007852948,0.00003680585,0.00004830648,0.9972187,0.00007062899,0.00001940496,0.0005085763],"study_design_scores_gemma":[0.00008010308,0.0006651535,0.01351427,0.00001089666,0.00003396277,0.0002515583,0.0001707626,0.0007655537,0.9836795,0.000139351,0.0006787627,0.00001020464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974815,0.000916968,0.0009677099,0.00008800803,0.00002003363,0.00001194031,0.0001104311,0.00002496318,0.0003785086],"genre_scores_gemma":[0.9964155,0.000742546,0.0009958951,0.00007175979,0.00001900876,0.00003680628,0.0002173148,0.0000191426,0.001482064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009825189,"threshold_uncertainty_score":0.003286839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013358618183774,"score_gpt":0.2869458071249988,"score_spread":0.266812220943161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}