{"id":"W2131243283","doi":"10.1093/intimm/dxp030","title":"Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses","year":2009,"lang":"en","type":"article","venue":"International Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"U.S. Public Health Service; Pfizer","keywords":"RNA; RNA silencing; Immune system; Gene silencing; Biology; Small interfering RNA; Cell biology; Nucleic acid; Sense (electronics); Innate immune system; Methylation; RNA interference; Chemistry; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003816934,0.0003022387,0.000466853,0.0004899011,0.0002122196,0.00003511893,0.0008548779,0.0004377166,0.000869817],"category_scores_gemma":[0.001123099,0.0002927333,0.0001952957,0.0001735916,0.000364237,0.0004643606,0.0001167646,0.0005581455,0.0005566577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678104,"about_ca_system_score_gemma":0.0002991022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005983601,"about_ca_topic_score_gemma":0.00001842153,"domain_scores_codex":[0.9974267,0.0006903207,0.0009679976,0.0003853913,0.0001208852,0.000408737],"domain_scores_gemma":[0.9972948,0.001136918,0.000642711,0.0004649516,0.000438967,0.00002166315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003019232,0.0001410735,0.0005401818,0.000002844704,0.001031187,0.00001910081,0.001949278,0.00002595296,0.9862774,0.00354942,0.000113736,0.003330617],"study_design_scores_gemma":[0.002200632,0.0003910327,0.1209775,0.0000735964,0.00006159249,0.00008110383,0.0009121733,0.0001223503,0.8651767,0.001122452,0.008567026,0.0003138541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874392,0.005489333,0.00005864777,0.002446506,0.001816315,0.0002772415,0.00007796094,0.0002008864,0.002193905],"genre_scores_gemma":[0.9965368,0.0005719512,0.0001958914,0.0002071293,0.00005403643,0.00003935309,0.001221331,0.00001966497,0.001153844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1211007,"threshold_uncertainty_score":0.9999525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114975153520309,"score_gpt":0.2608974682360652,"score_spread":0.2497477167008622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}