{"id":"W2131245007","doi":"10.1128/jvi.78.21.12062-12065.2004","title":"Statin Compounds Reduce Human Immunodeficiency Virus Type 1 Replication by Preventing the Interaction between Virion-Associated Host Intercellular Adhesion Molecule 1 and Its Natural Cell Surface Ligand LFA-1","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Virus; Intercellular Adhesion Molecule-1; Lymphocyte function-associated antigen 1; Viral replication; Virology; Intracellular; ICAM-1; Intercellular adhesion molecule; Host (biology); Cell adhesion; Infectivity; Cell adhesion molecule; Cell biology; Integrin; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006714209,0.0001404188,0.0002606605,0.00008439679,0.0003357925,0.00003022841,0.000214271,0.0001593529,0.00002656267],"category_scores_gemma":[0.0001573246,0.00009837029,0.00007213148,0.0001359399,0.0001190155,0.0001477015,0.00008516811,0.0006722765,0.00006873791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457824,"about_ca_system_score_gemma":0.00005765788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001149247,"about_ca_topic_score_gemma":0.00001486513,"domain_scores_codex":[0.9985788,0.0004194556,0.000455344,0.0002050307,0.00007086574,0.0002705333],"domain_scores_gemma":[0.9989081,0.0001788767,0.0005241497,0.0001755801,0.0001839505,0.00002933261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002072428,0.0002516382,0.001109437,0.000006833456,0.0001468716,0.00001041248,0.0006141293,0.00001407186,0.9968605,0.000009185508,0.0005218284,0.0002478583],"study_design_scores_gemma":[0.002152285,0.002013074,0.01331408,0.00006863107,0.00008880289,0.0001645762,0.0002635319,0.000009745343,0.9809704,0.00008256187,0.0007664379,0.0001058096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873503,0.01141375,0.00003950423,0.0007042114,0.0002116344,0.0001753662,0.00002564055,0.00001093983,0.00006861296],"genre_scores_gemma":[0.9988473,0.0005496775,0.00002281204,0.00004132653,0.00001967845,0.000002037867,0.0001623213,0.00001237075,0.0003424802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01589003,"threshold_uncertainty_score":0.4011424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864245658180973,"score_gpt":0.3011326082917042,"score_spread":0.2824901517098945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}