{"id":"W2131245007","doi":"10.1128/jvi.78.21.12062-12065.2004","title":"Statin Compounds Reduce Human Immunodeficiency Virus Type 1 Replication by Preventing the Interaction between Virion-Associated Host Intercellular Adhesion Molecule 1 and Its Natural Cell Surface Ligand LFA-1","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Virus; Intercellular Adhesion Molecule-1; Lymphocyte function-associated antigen 1; Viral replication; Virology; Intracellular; ICAM-1; Intercellular adhesion molecule; Host (biology); Cell adhesion; Infectivity; Cell adhesion molecule; Cell biology; Integrin; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736476,0.0002332243,0.0004908462,0.0001830043,0.0001940011,0.0002951149,0.0002393265,0.0003470841,0.001701531],"category_scores_gemma":[0.000304075,0.0000956318,0.0001667273,0.0001064202,0.00019795,0.0001762672,0.0001468109,0.00039708,0.0002555938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789128,"about_ca_system_score_gemma":0.0003940469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008601226,"about_ca_topic_score_gemma":0.002858025,"domain_scores_codex":[0.999863,0.00003584245,0.00001523976,0.00001014797,0.00003165285,0.00004402227],"domain_scores_gemma":[0.9999006,0.0000231787,0.00002133742,0.000008158018,0.00001653489,0.00003017536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006613968,0.001472372,0.002487064,0.0004344286,0.0001104011,0.0001925132,0.00007452467,0.0005193101,0.9435342,0.0008260131,0.0009091813,0.04282598],"study_design_scores_gemma":[0.0009179734,0.01465333,0.01675724,0.00004665618,0.000202216,0.000398948,0.0001140742,0.001475605,0.9555361,0.0002982008,0.009581576,0.00001811511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924115,0.004604252,0.0005556066,0.000197953,0.00006320856,0.00006899939,0.0001924762,0.00004114468,0.001864916],"genre_scores_gemma":[0.9922372,0.003165154,0.001359161,0.0001294997,0.0000344271,0.00004872477,0.0002913616,0.000007304998,0.002727304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001701531,"threshold_uncertainty_score":0.005692184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864245658180973,"score_gpt":0.3011326082917042,"score_spread":0.2824901517098945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}