{"id":"W2131252939","doi":"10.1186/2051-5960-2-61","title":"Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study","year":2014,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Merck Canada; Alzheimer Society; McGill University; Alzheimer's Association","keywords":"Genetically modified mouse; Intracellular; Pathology; Amyloid precursor protein; Amyloid (mycology); Extracellular; Neuroinflammation; Neuroscience; Transgene; Hyperphosphorylation; Chemistry; Biology; Alzheimer's disease; Psychology; Cell biology; Medicine; Biochemistry; Disease; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014435,0.0006184864,0.0002372771,0.0007440927,0.0001767136,0.0002919159,0.0001696429,0.0003170496,0.0005650086],"category_scores_gemma":[0.0001012394,0.0002135497,0.000332532,0.0002386871,0.0002679834,0.0003381454,0.0003298991,0.0004976945,0.0003244584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506053,"about_ca_system_score_gemma":0.0001286613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006143074,"about_ca_topic_score_gemma":0.0007944427,"domain_scores_codex":[0.9999118,0.000006466429,0.000009127489,0.00002700754,0.00002454737,0.00002101577],"domain_scores_gemma":[0.9997599,0.0000211025,0.00008785802,0.000022566,0.00004244353,0.0000662512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005764435,0.00002536614,0.0002763664,0.00001130556,0.00000428462,0.00005873018,0.00002200614,0.000012499,0.9992229,0.00001413636,0.000004321121,0.000290477],"study_design_scores_gemma":[0.00002228733,0.00114873,0.06109447,0.00001500001,0.0001060346,0.002579476,0.0001692817,0.001422576,0.9321347,0.0002317958,0.001046511,0.00002908496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994814,0.0009031135,0.003563495,0.00003491985,0.0000131894,0.00001977174,0.0001777401,0.00005378484,0.0004200659],"genre_scores_gemma":[0.9853165,0.001744649,0.01052803,0.00004966923,0.00001911176,0.00005245267,0.0004472159,0.00003312479,0.001809266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007440927,"threshold_uncertainty_score":0.001890182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04557778467119913,"score_gpt":0.3324729944350321,"score_spread":0.286895209763833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}