{"id":"W2131260862","doi":"10.2337/db12-1010","title":"Inhibition of Src Kinase Blocks High Glucose–Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Diabetes Canada; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Proto-oncogene tyrosine-protein kinase Src; Internal medicine; Endocrinology; Kinase; Chemistry; MAPK/ERK pathway; Tyrosine kinase; Cancer research; Signal transduction; Cell biology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003257298,0.0008375867,0.0005241108,0.0004906852,0.0002424775,0.0002861595,0.0004766017,0.0004662326,0.001738735],"category_scores_gemma":[0.0001175755,0.0003966069,0.0005763134,0.0002817059,0.0003147433,0.0002681713,0.0001916625,0.001292174,0.0006094246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003134326,"about_ca_system_score_gemma":0.000409512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000969678,"about_ca_topic_score_gemma":0.001793393,"domain_scores_codex":[0.9996216,0.0000660135,0.0000507298,0.00005518644,0.00007756572,0.000128852],"domain_scores_gemma":[0.9998203,0.00001573572,0.00005233058,0.00002418453,0.00001593336,0.00007152612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005336627,0.0003213296,0.0001299855,0.00005661898,0.00001558961,0.00004706865,0.00001755052,0.00008403732,0.9969435,0.0001464967,0.0001280383,0.001576154],"study_design_scores_gemma":[0.000239001,0.002045951,0.004559349,0.00001662945,0.0000488976,0.0002487864,0.00003390056,0.001658178,0.9880255,0.00007596665,0.003038686,0.000009202274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905372,0.002071468,0.003435472,0.0002997837,0.0001469939,0.0001206737,0.0007792199,0.0003449022,0.0022643],"genre_scores_gemma":[0.9871329,0.002312001,0.003044237,0.0001352461,0.00004482704,0.0002112748,0.001254697,0.00005963568,0.005805199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001738735,"threshold_uncertainty_score":0.005816638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006199104328194814,"score_gpt":0.2050132775740583,"score_spread":0.1988141732458635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}