{"id":"W2131294164","doi":"10.1128/jvi.02046-10","title":"Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and Translation","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Biology; Argonaute; NS2-3 protease; RNA; Translation (biology); Small interfering RNA; Internal ribosome entry site; Gene silencing; microRNA; Hepatitis C virus; Untranslated region; Virology; RNA interference; Viral replication; RNA silencing; Gene knockdown; Cell biology; Molecular biology; Small RNA; Messenger RNA; Virus; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003319978,0.0001016427,0.0001847232,0.0001129934,0.00006298967,0.000009600893,0.00008619743,0.0002259718,0.00001433856],"category_scores_gemma":[0.0000652181,0.0001004552,0.000117385,0.00004830614,0.00009867401,0.00001089033,0.00001738691,0.00008596659,5.435293e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001090643,"about_ca_system_score_gemma":0.00004251225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001550971,"about_ca_topic_score_gemma":0.00006173045,"domain_scores_codex":[0.9990801,0.00005397135,0.000488082,0.00015296,0.0001075077,0.000117431],"domain_scores_gemma":[0.9989259,0.00002350945,0.0005990104,0.0001585556,0.0002370586,0.00005594332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002578715,0.0000902682,0.001425522,0.00002594847,0.00004780889,4.099959e-7,0.00009647817,0.0005799271,0.9935613,0.0000914772,0.0002719412,0.003551046],"study_design_scores_gemma":[0.001957099,0.0005650317,0.1485468,0.00001298509,0.00008598447,0.00004292931,0.000005403045,0.003050487,0.8422501,0.0007483152,0.002628125,0.0001066749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911335,0.0003606124,0.007778888,0.0002752981,0.0001997345,0.0002020481,0.00002724905,0.000004961584,0.00001770601],"genre_scores_gemma":[0.9965159,0.00004845937,0.003023625,0.00007079556,0.0002625175,0.000003452901,0.00003956891,0.00002400887,0.00001164326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1513112,"threshold_uncertainty_score":0.4096444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045998134809234,"score_gpt":0.3005510279637668,"score_spread":0.2800910466156744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}