{"id":"W2131294164","doi":"10.1128/jvi.02046-10","title":"Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and Translation","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Biology; Argonaute; NS2-3 protease; RNA; Translation (biology); Small interfering RNA; Internal ribosome entry site; Gene silencing; microRNA; Hepatitis C virus; Untranslated region; Virology; RNA interference; Viral replication; RNA silencing; Gene knockdown; Cell biology; Molecular biology; Small RNA; Messenger RNA; Virus; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002420426,0.0004853184,0.0003615303,0.0002702552,0.0003941583,0.000455779,0.0002949898,0.000356264,0.002036165],"category_scores_gemma":[0.0003117328,0.0003545716,0.0004261806,0.0001552073,0.0002541094,0.0001881719,0.0003572713,0.0005125324,0.001643446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004477704,"about_ca_system_score_gemma":0.000372729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009555725,"about_ca_topic_score_gemma":0.001501952,"domain_scores_codex":[0.9996548,0.00005597386,0.00004346907,0.00007547875,0.0001273498,0.00004287922],"domain_scores_gemma":[0.9997827,0.00003447704,0.0000429447,0.00002709367,0.00003641199,0.00007635255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009060957,0.00002251451,0.0001588509,0.00003043141,0.000006329432,0.0000966909,0.00001127805,0.00003953757,0.9985464,0.00011572,0.0001133946,0.0007681816],"study_design_scores_gemma":[0.00004698892,0.0001419094,0.01091865,0.00001114048,0.00001933205,0.0009190377,0.00002266319,0.004293057,0.9721311,0.0001095844,0.01136473,0.0000217811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629539,0.003737031,0.02042372,0.0004203082,0.0003479423,0.0001629899,0.002636172,0.0009021168,0.008415994],"genre_scores_gemma":[0.9802845,0.0005541613,0.007745415,0.0001837875,0.00004157599,0.0001207658,0.003360805,0.0001972621,0.007511844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036165,"threshold_uncertainty_score":0.006811619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045998134809234,"score_gpt":0.3005510279637668,"score_spread":0.2800910466156744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}