{"id":"W2131295941","doi":"10.7326/0003-4819-151-8-200910200-00006","title":"Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture","year":2009,"lang":"en","type":"review","venue":"Annals of Internal Medicine","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; European Commission; Canadian Institutes of Health Research; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Helsingin Yliopisto","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Candidate gene; International HapMap Project; Osteoporosis; Medicine; Genetics; Haplotype; Population; Femoral neck; Genetic association; SNP; Internal medicine; Bioinformatics; Biology; Allele; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001345723,0.0006409352,0.009279587,0.001309387,0.00007360568,0.00001426484,0.0002811575,0.0004165387,0.0006040047],"category_scores_gemma":[0.0006985596,0.0003472505,0.001248779,0.002158602,0.00039362,0.00009383411,0.00006450497,0.0007917737,0.000004613346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005219097,"about_ca_system_score_gemma":0.001034502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001960307,"about_ca_topic_score_gemma":0.0006735288,"domain_scores_codex":[0.9951044,0.000435409,0.002060503,0.0005960026,0.001301274,0.0005024456],"domain_scores_gemma":[0.9933953,0.0008288207,0.002383126,0.0006862799,0.002129405,0.000577084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0008238812,0.0006754154,0.001003637,0.03732558,0.4357281,0.0003126214,0.00268033,0.000007029943,0.00001234902,0.00007169744,0.01519555,0.5061638],"study_design_scores_gemma":[0.0014944,0.006563217,0.001444507,0.008703205,0.51165,0.0001544106,0.0008652694,0.00000747454,0.0001519191,0.0000394444,0.468486,0.0004402003],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002146425,0.9920793,0.00001769084,0.004808608,0.00003970777,0.001467031,0.0005255628,0.00001673216,0.0008306932],"genre_scores_gemma":[0.002703295,0.9933844,0.0002652344,0.002025999,0.0001626652,0.00009554861,0.0004453345,0.0000486764,0.0008688632],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5057236,"threshold_uncertainty_score":0.999898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1311182318198569,"score_gpt":0.4497346251993466,"score_spread":0.3186163933794897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}