{"id":"W2131295941","doi":"10.7326/0003-4819-151-8-200910200-00006","title":"Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture","year":2009,"lang":"en","type":"review","venue":"Annals of Internal Medicine","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; European Commission; Canadian Institutes of Health Research; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Helsingin Yliopisto","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Candidate gene; International HapMap Project; Osteoporosis; Medicine; Genetics; Haplotype; Population; Femoral neck; Genetic association; SNP; Internal medicine; Bioinformatics; Biology; Allele; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01815872,0.002903999,0.01256627,0.006148407,0.001163972,0.002806771,0.002614005,0.002387372,0.002425461],"category_scores_gemma":[0.04029256,0.001368161,0.03756713,0.0103135,0.0007342751,0.001092538,0.001598227,0.001962087,0.0002836412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001489875,"about_ca_system_score_gemma":0.002760977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01226231,"about_ca_topic_score_gemma":0.01530355,"domain_scores_codex":[0.9747677,0.01525478,0.003381521,0.003986784,0.002032296,0.0005769182],"domain_scores_gemma":[0.9656428,0.02650793,0.003059713,0.002645053,0.001609228,0.0005354346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003518663,0.00002986559,0.05202199,0.01369828,0.9215963,0.0002810944,0.00004371992,0.00152332,0.0003114649,0.0001349736,0.001133549,0.005706837],"study_design_scores_gemma":[0.001604797,0.0002433371,0.02390235,0.001318454,0.969918,0.0002253897,0.00002708732,0.001266613,0.0001584386,0.0003856538,0.0009207467,0.00002918076],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.121253,0.8597502,0.008723281,0.001249479,0.0008865565,0.0005477246,0.006026775,0.0003336829,0.001229267],"genre_scores_gemma":[0.8870752,0.09803412,0.007574866,0.0008818281,0.0005364164,0.0009813054,0.004317994,0.000123184,0.0004749722],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01815872,"threshold_uncertainty_score":0.09603363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1311182318198569,"score_gpt":0.4497346251993466,"score_spread":0.3186163933794897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}