{"id":"W2131302778","doi":"10.1139/h2012-009","title":"mTORC1 and the regulation of skeletal muscle anabolism and mass","year":2012,"lang":"en","type":"review","venue":"Applied Physiology Nutrition and Metabolism","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"mTORC1; Wasting; Skeletal muscle; Insulin resistance; Anabolism; Endocrinology; Medicine; Internal medicine; Mechanistic target of rapamycin; Sarcopenia; Bioinformatics; Biology; PI3K/AKT/mTOR pathway; Diabetes mellitus; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002494971,0.0007995356,0.001037615,0.001694615,0.0002945334,0.0008843998,0.0006658743,0.001060202,0.002244581],"category_scores_gemma":[0.0002583828,0.0002489841,0.0003343143,0.001876998,0.0003953995,0.0009061723,0.0006030063,0.001311786,0.002385962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007218434,"about_ca_system_score_gemma":0.0009578637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030105,"about_ca_topic_score_gemma":0.001328754,"domain_scores_codex":[0.9998693,0.00001813283,0.00001722249,0.00002615216,0.00005269578,0.00001646993],"domain_scores_gemma":[0.9999291,0.00001788069,0.00001371244,0.000002409795,0.00002503905,0.00001190127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001408182,0.00008428045,0.0002283686,0.01418226,0.00009404092,0.0004198252,0.00006910351,0.0005821832,0.007796899,0.006141711,0.0323661,0.9378944],"study_design_scores_gemma":[0.0000168403,0.00007720327,0.001351565,0.001173221,0.00006070964,0.001496389,0.0000444113,0.0001528548,0.001640025,0.002624294,0.991342,0.00002041061],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002049891,0.9979643,0.0001806006,0.0002184094,0.0001570895,0.000004283032,0.00001894214,0.00001072822,0.001240682],"genre_scores_gemma":[0.001121807,0.9974491,0.0002012872,0.0001090358,0.0001263473,0.000008187191,0.00003540615,0.000001962014,0.0009469174],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002244581,"threshold_uncertainty_score":0.007508934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641370529308397,"score_gpt":0.2691852461187361,"score_spread":0.2527715408256521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}