{"id":"W2131310300","doi":"10.1128/aac.48.7.2415-2423.2004","title":"Efflux Pump-Mediated Intrinsic Drug Resistance in <i>Mycobacterium smegmatis</i>","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Universidad de Zaragoza; University of Toronto","keywords":"Acriflavine; Ethidium bromide; Mycobacterium smegmatis; Efflux; TetR; Biology; Mutant; Gene; Microbiology; Antibacterial agent; Molecular biology; Mycobacterium tuberculosis; Repressor; Genetics; Gene expression; Antibiotics; DNA; Tuberculosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593021,0.0002475586,0.0003020937,0.0001504964,0.0001023159,0.0002832502,0.0001590732,0.0002286828,0.0007406817],"category_scores_gemma":[0.0002258139,0.0001266888,0.0003409559,0.0001312824,0.0001647591,0.0001852823,0.0001685892,0.0004273368,0.0004026675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004570262,"about_ca_system_score_gemma":0.0001853254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247872,"about_ca_topic_score_gemma":0.001239156,"domain_scores_codex":[0.9998041,0.00003383349,0.00002705745,0.00003850998,0.00006135867,0.000035108],"domain_scores_gemma":[0.9998821,0.00002133689,0.00003957607,0.0000200473,0.00002443949,0.00001246903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002672506,0.000007753634,0.0004082412,0.00002980313,0.000002685763,0.00003640624,0.000009001606,0.00003287292,0.9987109,0.00003523737,0.00002239687,0.0006780247],"study_design_scores_gemma":[0.000009273427,0.0001818575,0.008441295,0.000008336321,0.00001696124,0.0005593166,0.00002371165,0.0007801272,0.98783,0.00003852845,0.002104303,0.000006316237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923954,0.0011181,0.004596875,0.0001476224,0.00002665921,0.00002788101,0.0008387085,0.0001288496,0.0007200197],"genre_scores_gemma":[0.9916229,0.0004938129,0.00422139,0.00006635267,0.00001153325,0.00002641467,0.001667383,0.00004541226,0.001844794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247872,"threshold_uncertainty_score":0.003316045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148528597798478,"score_gpt":0.273075468045651,"score_spread":0.2615901820676663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}