{"id":"W2131332104","doi":"10.1016/s0006-3223(01)01110-6","title":"Ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine d2 receptor","year":2001,"lang":"en","type":"letter","venue":"Biological Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Dopamine; Dopamine receptor D2; Psychology; Dopamine receptor; Dopamine hypothesis of schizophrenia; Antipsychotic; Schizophrenia (object-oriented programming); Neuroscience; Pharmacology; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006244545,0.0004640892,0.001025929,0.0001449968,0.0009018763,0.001086847,0.0005368582,0.009102878,0.004230189],"category_scores_gemma":[0.006289467,0.0001849459,0.0004418165,0.0002080332,0.001200878,0.001075675,0.0003213707,0.006224772,0.00195288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001484795,"about_ca_system_score_gemma":0.0004113962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009442848,"about_ca_topic_score_gemma":0.002132906,"domain_scores_codex":[0.9996163,0.0001116712,0.00004674493,0.00005276657,0.00009212286,0.00008048167],"domain_scores_gemma":[0.9985785,0.0008575594,0.0001517653,0.00008992885,0.0001484307,0.0001737641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005615465,0.0003794581,0.01325905,0.0007578612,0.0003281189,0.1189014,0.0006503626,0.0004915429,0.0195292,0.02057469,0.6727544,0.1467586],"study_design_scores_gemma":[0.002112658,0.002726469,0.03226141,0.0002795844,0.0003493562,0.1379022,0.00120411,0.002916712,0.01669783,0.02989168,0.7734568,0.0002012654],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.05819063,0.006446902,0.001549777,0.8803505,0.02268469,0.00006478494,0.0002220977,0.0001384518,0.03035224],"genre_scores_gemma":[0.4622503,0.009487912,0.001948346,0.4243797,0.05832209,0.0001359889,0.0002617293,0.00008095887,0.04313304],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009102878,"threshold_uncertainty_score":0.01415145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07391606483117108,"score_gpt":0.2794959030694299,"score_spread":0.2055798382382588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}